{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li J"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","NIA NIH HHS","National Institutes of Health","NIAMS NIH HHS","National Institute on Aging","NIH HHS","Penn Center for Musculoskeletal Disorders"],"pagination":["161-176"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11323896"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(2)"],"pubmed_abstract":["Osteoarthritis (OA) affects multiple tissues in the knee joint, including the synovium and intra-articular adipose tissue (IAAT) that are attached to each other. However, whether these two tissues share the same progenitor cells and hence function as a single unit in joint homeostasis and diseases is largely unknown. Single-cell transcriptomic profiling of synovium and infrapatellar fat pad (IFP), the largest IAAT, from control and OA mice revealed five mesenchymal clusters and predicted mesenchymal progenitor cells (MPCs) as the common progenitors for other cells: synovial lining fibroblasts (SLFs), myofibroblasts (MFs), and preadipocytes 1 and 2. Histologic examination of joints in reporter mice having Dpp4-CreER and Prg4-CreER that label MPCs and SLFs, respectively, demonstrated that Dp"],"journal":["Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research"],"pubmed_title":["Synovium and infrapatellar fat pad share common mesenchymal progenitors and undergo coordinated changes in osteoarthritis."],"pmcid":["PMC11323896"],"funding_grant_id":["R01 AG067698","R21 AR074570","P30 AR069619","R21 AR078650","R21AR074570","R21AR078650","R01 AR079875","R01AG067698","P30AR069619","R01AR079875"],"pubmed_authors":["Yao L","Li J","Dyment N","Qin L","Lin YL","Duffy M","Gui T","Seale P","Guo H","Zgonis M","Zhang Y","Lu J","Scanzello C","Mauck R"],"additional_accession":[]},"is_claimable":false,"name":"Synovium and infrapatellar fat pad share common mesenchymal progenitors and undergo coordinated changes in osteoarthritis.","description":"Osteoarthritis (OA) affects multiple tissues in the knee joint, including the synovium and intra-articular adipose tissue (IAAT) that are attached to each other. However, whether these two tissues share the same progenitor cells and hence function as a single unit in joint homeostasis and diseases is largely unknown. Single-cell transcriptomic profiling of synovium and infrapatellar fat pad (IFP), the largest IAAT, from control and OA mice revealed five mesenchymal clusters and predicted mesenchymal progenitor cells (MPCs) as the common progenitors for other cells: synovial lining fibroblasts (SLFs), myofibroblasts (MFs), and preadipocytes 1 and 2. Histologic examination of joints in reporter mice having Dpp4-CreER and Prg4-CreER that label MPCs and SLFs, respectively, demonstrated that Dp","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-22T09:00:34.506Z","creation":"2025-04-05T22:52:28.075Z"},"accession":"S-EPMC11323896","cross_references":{"pubmed":["38477740"],"doi":["10.1093/jbmr/zjad009"]}}