{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ripamonte GC"],"funding":["National Institute of Environmental Health Sciences","FAPESP","Intramural NIH HHS","CNPq","CAPES"],"pagination":["111063"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11323958"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["134"],"pubmed_abstract":["CO<sub>2</sub> exposure has been used to investigate the panicogenic response in patients with panic disorder. These patients are more sensitive to CO<sub>2</sub>, and more likely to experience the \"false suffocation alarm\" which triggers panic attacks. Imbalances in locus coeruleus noradrenergic (LC-NA) neurotransmission are responsible for psychiatric disorders, including panic disorder. These neurons are sensitive to changes in CO<sub>2</sub>/pH. Therefore, we investigated if LC-NA neurons are differentially activated after severe hypercapnia in mice. Further, we evaluated the participation of LC-NA neurons in ventilatory and panic-like escape responses induced by 20% CO<sub>2</sub> in male and female wild type mice and two mouse models of altered LC-NA synthesis. Hypercapnia activates "],"journal":["Progress in neuro-psychopharmacology & biological psychiatry"],"pubmed_title":["Locus coeruleus noradrenaline depletion and its differential impact on CO&lt;sub&gt;2&lt;/sub&gt;-induced panic and hyperventilation in male and female mice."],"pmcid":["PMC11323958"],"funding_grant_id":["ZIA ES102805"],"pubmed_authors":["Silva KSC","Zangrossi H","Frias AT","Plummer NW","Patrone LGA","Bicego KC","Vilela-Costa HH","Ripamonte GC","Fonseca EM","Szawka RE","Jensen P","Gargaglioni LH"],"additional_accession":[]},"is_claimable":false,"name":"Locus coeruleus noradrenaline depletion and its differential impact on CO&lt;sub&gt;2&lt;/sub&gt;-induced panic and hyperventilation in male and female mice.","description":"CO<sub>2</sub> exposure has been used to investigate the panicogenic response in patients with panic disorder. These patients are more sensitive to CO<sub>2</sub>, and more likely to experience the \"false suffocation alarm\" which triggers panic attacks. Imbalances in locus coeruleus noradrenergic (LC-NA) neurotransmission are responsible for psychiatric disorders, including panic disorder. These neurons are sensitive to changes in CO<sub>2</sub>/pH. Therefore, we investigated if LC-NA neurons are differentially activated after severe hypercapnia in mice. Further, we evaluated the participation of LC-NA neurons in ventilatory and panic-like escape responses induced by 20% CO<sub>2</sub> in male and female wild type mice and two mouse models of altered LC-NA synthesis. Hypercapnia activates ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-05-28T02:19:57.947Z","creation":"2026-04-08T02:07:45.371Z"},"accession":"S-EPMC11323958","cross_references":{"pubmed":["38908504"],"doi":["10.1016/j.pnpbp.2024.111063"]}}