{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Singh G"],"funding":["Science and Engineering Research Board"],"pagination":["2826-2854"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11324062"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(8)"],"pubmed_abstract":["Twelve 3,5-disubstituted-thiazolidine-2,4-dione (TZD) hybrids were synthesized using solution phase chemistry. Continuing our previous work, nine <i>O</i>-modified ethyl vanillin (8a-i) derivatives were synthesized and reacted with the TZD core <i>via</i> Knoevenagel condensation under primary reaction conditions to obtain final derivatives 9a-i. Additionally, three isatin-TZD hybrids (11a-c) were synthesized. The intermediates and final derivatives were characterized using <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy, and the observed chemical shifts agreed with the proposed structures. The <i>in vitro</i> alpha-amylase and alpha-glucosidase inhibitory evaluation of newly synthesized derivatives revealed compounds 9F and 9G as the best dual inhibitors, with IC<sub>50</sub> values of "],"journal":["RSC medicinal chemistry"],"pubmed_title":["Thiazolidine-2,4-dione hybrids as dual alpha-amylase and alpha-glucosidase inhibitors: design, synthesis, &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; anti-diabetic evaluation."],"pmcid":["PMC11324062"],"funding_grant_id":["CRG/2021/001009"],"pubmed_authors":["Singh G","Mehan S","Monga V","Singh R"],"additional_accession":[]},"is_claimable":false,"name":"Thiazolidine-2,4-dione hybrids as dual alpha-amylase and alpha-glucosidase inhibitors: design, synthesis, &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; anti-diabetic evaluation.","description":"Twelve 3,5-disubstituted-thiazolidine-2,4-dione (TZD) hybrids were synthesized using solution phase chemistry. Continuing our previous work, nine <i>O</i>-modified ethyl vanillin (8a-i) derivatives were synthesized and reacted with the TZD core <i>via</i> Knoevenagel condensation under primary reaction conditions to obtain final derivatives 9a-i. Additionally, three isatin-TZD hybrids (11a-c) were synthesized. The intermediates and final derivatives were characterized using <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy, and the observed chemical shifts agreed with the proposed structures. The <i>in vitro</i> alpha-amylase and alpha-glucosidase inhibitory evaluation of newly synthesized derivatives revealed compounds 9F and 9G as the best dual inhibitors, with IC<sub>50</sub> values of ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-03-27T15:51:00.118Z","creation":"2025-08-24T03:08:48.901Z"},"accession":"S-EPMC11324062","cross_references":{"pubmed":["39149094"],"doi":["10.1039/d4md00199k"]}}