{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mihajlovic M"],"funding":["HORIZON EUROPE Excellent Science","Alternatives Research and Development Foundation","Center for Alternatives to Animal Testing, Johns Hopkins Bloomberg School of Public Health","University Hospital of the Vrije Universiteit Brussel","Vrije Universiteit Brussel","Research Foundation Flanders","Flemish Government"],"pagination":["3109-3126"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11324701"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["98(9)"],"pubmed_abstract":["Parenteral nutrition (PN) is typically administered to individuals with gastrointestinal dysfunction, a contraindication for enteral feeding, and a need for nutritional therapy. When PN is the only energy source in patients, it is defined as total parenteral nutrition (TPN). TPN is a life-saving approach for different patient populations, both in infants and adults. However, despite numerous benefits, TPN can cause adverse effects, including metabolic disorders and liver injury. TPN-associated liver injury, known as intestinal failure-associated liver disease (IFALD), represents a significant problem affecting up to 90% of individuals receiving TPN. IFALD pathogenesis is complex, depending on the TPN components as well as on the patient's medical conditions. Despite numerous animal studies"],"journal":["Archives of toxicology"],"pubmed_title":["Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures."],"pmcid":["PMC11324701"],"funding_grant_id":["101034352","Methusalem Grant","Scientific Fund Willy Gepts","Industrial Research Fund"],"pubmed_authors":["Mihajlovic M","Tabernilla A","De Waele E","Verhoeven A","Maerten A","Callewaert E","De Boever S","Vinken M","Sanz-Serrano J","Rosseel Z"],"additional_accession":[]},"is_claimable":false,"name":"Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures.","description":"Parenteral nutrition (PN) is typically administered to individuals with gastrointestinal dysfunction, a contraindication for enteral feeding, and a need for nutritional therapy. When PN is the only energy source in patients, it is defined as total parenteral nutrition (TPN). TPN is a life-saving approach for different patient populations, both in infants and adults. However, despite numerous benefits, TPN can cause adverse effects, including metabolic disorders and liver injury. TPN-associated liver injury, known as intestinal failure-associated liver disease (IFALD), represents a significant problem affecting up to 90% of individuals receiving TPN. IFALD pathogenesis is complex, depending on the TPN components as well as on the patient's medical conditions. Despite numerous animal studies","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-05-18T12:15:28.152Z","creation":"2025-04-05T10:09:49.599Z"},"accession":"S-EPMC11324701","cross_references":{"pubmed":["38740588"],"doi":["10.1007/s00204-024-03773-8"]}}