biostudies-literatureUnknown103(9)Zhao Y<h4>Introduction</h4>Clinical practice guidelines provide inconsistent recommendations regarding progestogen supplementation for threatened and recurrent miscarriage. We conducted a systematic review and meta-analysis to assess the effectiveness and safety of progestogens for these patients.<h4>Material and methods</h4>We searched Medline, Embase, and Cochrane Central Registry of Controlled Trials up to October 6, 2023 for randomized control trials (RCTs) comparing progestogen supplementation to placebo or no treatment for pregnant women with threatened or recurrent miscarriage. We assessed the risk of bias using a modified version of the Cochrane risk-of-bias tool and the certainty of evidence using the GRADE approach.<h4>Results</h4>Of 15 RCTs (6616 pregnancies) reporting on threatened oActa obstetricia et gynecologica Scandinavica1689-1701https://www.ebi.ac.uk/biostudies/studies/S-EPMC11324929biostudies-literatureProgestogens in women with threatened miscarriage or recurrent miscarriage: A meta-analysis.PMC11324929Hao QKallas-Silva LSteen JPGao YGuyatt GD'Souza RZhao YfalseProgestogens in women with threatened miscarriage or recurrent miscarriage: A meta-analysis.<h4>Introduction</h4>Clinical practice guidelines provide inconsistent recommendations regarding progestogen supplementation for threatened and recurrent miscarriage. We conducted a systematic review and meta-analysis to assess the effectiveness and safety of progestogens for these patients.<h4>Material and methods</h4>We searched Medline, Embase, and Cochrane Central Registry of Controlled Trials up to October 6, 2023 for randomized control trials (RCTs) comparing progestogen supplementation to placebo or no treatment for pregnant women with threatened or recurrent miscarriage. We assessed the risk of bias using a modified version of the Cochrane risk-of-bias tool and the certainty of evidence using the GRADE approach.<h4>Results</h4>Of 15 RCTs (6616 pregnancies) reporting on threatened o2024-01-01T00:00:00Z2024 Sep2025-05-18T12:13:08.022Z2025-04-05T10:10:08.973ZS-EPMC113249293848103110.1111/aogs.14829