biostudies-literatureStamellou EDeutsche Forschungsgemeinschaftsfae230https://www.ebi.ac.uk/biostudies/studies/S-EPMC11324945biostudies-literatureUnknown17(8)<h4>Background</h4>The importance of albuminuria as opposed to proteinuria in predicting kidney outcomes in primary immunoglobulin A nephropathy (IgAN) is not well established.<h4>Methods</h4>From 2010 to 2012, 421 patients with biopsy-proven IgAN have been enrolled into the German Chronic Kidney Disease (GCKD) cohort, a prospective observational cohort study (<i>N</i> = 5217). Adjudicated endpoints include a composite kidney endpoint (CKE) consisting of eGFR decline >40%, eGFR <15 ml/min/1.73 m² and initiation of kidney replacement therapy; the individual components of the CKE; and combined major adverse cardiac events (MACE), including non-fatal myocardial infarction, non-fatal stroke and all-cause mortality. The associations between the incidence of CKE and baseline factors, Clinical kidney journalLong-term outcomes of patients with IgA nephropathy in the German CKD cohort.PMC11324945445703531Schiffer MBauer BMeder SEckardt KUSchaeffner EWeissensteiner HKronenberg FWanner CKotsis FSaritas TBechtel-Walz WForer LFloege JMitsch ESchmidt-Ott KStamellou ESchonherr SGronwald WKottgen AEkici ABHendry BKollerits BProkosch HUReis ABeck AAlberth-Schmidt UBusch MRaschenberger JBarthlein BSchultheiß UTTheisen KBaid-Agrawal SOefner PReinhard UMercer ABecker SSchmid MSteiner ASchneider MPKramann RZeier MNadal JWolf GWalz GKrane VAykac MSitter TMoeller MJMeiselbach HSommerer CSeikrit CMarschall SGCKD study investigatorsWeigel AfalseLong-term outcomes of patients with IgA nephropathy in the German CKD cohort.<h4>Background</h4>The importance of albuminuria as opposed to proteinuria in predicting kidney outcomes in primary immunoglobulin A nephropathy (IgAN) is not well established.<h4>Methods</h4>From 2010 to 2012, 421 patients with biopsy-proven IgAN have been enrolled into the German Chronic Kidney Disease (GCKD) cohort, a prospective observational cohort study (<i>N</i> = 5217). Adjudicated endpoints include a composite kidney endpoint (CKE) consisting of eGFR decline >40%, eGFR <15 ml/min/1.73 m² and initiation of kidney replacement therapy; the individual components of the CKE; and combined major adverse cardiac events (MACE), including non-fatal myocardial infarction, non-fatal stroke and all-cause mortality. The associations between the incidence of CKE and baseline factors, 2024-01-01T00:00:00Z2024 Aug2025-05-18T12:13:37.746Z2025-04-05T10:09:35.353ZS-EPMC113249453914909010.1093/ckj/sfae230