{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26"],"submitter":["Markovic A"],"pubmed_abstract":["<h4>Background</h4>Rapid development and implementation of vaccines constituted a crucial step in containing the COVID-19 pandemic. A comprehensive understanding of physiological responses to these vaccines is important to build trust in medicine.<h4>Objective</h4>This study aims to investigate temporal dynamics before and after COVID-19 vaccination in 4 physiological parameters as well as the duration of menstrual cycle phases.<h4>Methods</h4>In a prospective trial, 17,825 adults in the Netherlands wore a medical device on their wrist for up to 9 months. The device recorded their physiological signals and synchronized with a complementary smartphone app. By means of multilevel quadratic regression, we examined changes in wearable-recorded breathing rate, wrist skin temperature, heart rate"],"journal":["Journal of medical Internet research"],"pagination":["e51120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11325110"],"repository":["biostudies-literature"],"pubmed_title":["Physiological Response to the COVID-19 Vaccine: Insights From a Prospective, Randomized, Single-Blinded, Crossover Trial."],"pmcid":["PMC11325110"],"pubmed_authors":["Leurink T","Stromstad J","Downward G","Houtman E","Weideli O","Korkmaz S","Yalvac G","Denaxas S","Loeff F","Fernandez Medina P","Steenhuis M","Reitsma H","Bruijning P","Stolk P","Commandeur N","Risch M","Verhulst M","Fredslund E","Veen D","Risch L","Oberski D","Vigot N","Downward GS","Burggraaff J","Fevrier J","Grobbee D","Kuchta A","Van Dijk H","Brakenhoff TB","Rudinac M","van Willigen M","Hoffmann M","van Scherpenzeel W","Montes S","Rispens T","Christianawati O","Keijzer S","Bouwman","Hage K","Boogaard A","Choi J","van der Meer P","COVID-19 Remote Early Detection (COVID-RED) consortium","Grossmann K","Markovic A","Aarts W","Kovacevic V","Hehakaya C","van de Wijgert J","Dutman E","Mitratza M","Mitratza","Klaver P","Cronin M","Dowling A","Goodale B","Brakenhoff T","Grobbee DE","de Vink N","Dobson R","Goodale BM","Folarin A","Broersen J","Van Wigcheren G","Keijser J","Elmouhajir I","Franks B","Smets L","Heikamp T","Jansen M","Emby S","Simon C"],"additional_accession":[]},"is_claimable":false,"name":"Physiological Response to the COVID-19 Vaccine: Insights From a Prospective, Randomized, Single-Blinded, Crossover Trial.","description":"<h4>Background</h4>Rapid development and implementation of vaccines constituted a crucial step in containing the COVID-19 pandemic. A comprehensive understanding of physiological responses to these vaccines is important to build trust in medicine.<h4>Objective</h4>This study aims to investigate temporal dynamics before and after COVID-19 vaccination in 4 physiological parameters as well as the duration of menstrual cycle phases.<h4>Methods</h4>In a prospective trial, 17,825 adults in the Netherlands wore a medical device on their wrist for up to 9 months. The device recorded their physiological signals and synchronized with a complementary smartphone app. By means of multilevel quadratic regression, we examined changes in wearable-recorded breathing rate, wrist skin temperature, heart rate","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-01T16:26:49.735Z","creation":"2026-04-08T14:09:45.196Z"},"accession":"S-EPMC11325110","cross_references":{"pubmed":["39083770"],"doi":["10.2196/51120"]}}