biostudies-literatureUnknown26Markovic A<h4>Background</h4>Rapid development and implementation of vaccines constituted a crucial step in containing the COVID-19 pandemic. A comprehensive understanding of physiological responses to these vaccines is important to build trust in medicine.<h4>Objective</h4>This study aims to investigate temporal dynamics before and after COVID-19 vaccination in 4 physiological parameters as well as the duration of menstrual cycle phases.<h4>Methods</h4>In a prospective trial, 17,825 adults in the Netherlands wore a medical device on their wrist for up to 9 months. The device recorded their physiological signals and synchronized with a complementary smartphone app. By means of multilevel quadratic regression, we examined changes in wearable-recorded breathing rate, wrist skin temperature, heart rateJournal of medical Internet researche51120https://www.ebi.ac.uk/biostudies/studies/S-EPMC11325110biostudies-literaturePhysiological Response to the COVID-19 Vaccine: Insights From a Prospective, Randomized, Single-Blinded, Crossover Trial.PMC11325110Leurink TStromstad JDownward GHoutman EWeideli OKorkmaz SYalvac GDenaxas SLoeff FFernandez Medina PSteenhuis MReitsma HBruijning PStolk PCommandeur NRisch MVerhulst MFredslund EVeen DRisch LOberski DVigot NDownward GSBurggraaff JFevrier JGrobbee DKuchta AVan Dijk HBrakenhoff TBRudinac Mvan Willigen MHoffmann Mvan Scherpenzeel WMontes SRispens TChristianawati OKeijzer SBouwmanHage KBoogaard AChoi Jvan der Meer PCOVID-19 Remote Early Detection (COVID-RED) consortiumGrossmann KMarkovic AAarts WKovacevic VHehakaya Cvan de Wijgert JDutman EMitratza MMitratzaKlaver PCronin MDowling AGoodale BBrakenhoff TGrobbee DEde Vink NDobson RGoodale BMFolarin ABroersen JVan Wigcheren GKeijser JElmouhajir IFranks BSmets LHeikamp TJansen MEmby SSimon CfalsePhysiological Response to the COVID-19 Vaccine: Insights From a Prospective, Randomized, Single-Blinded, Crossover Trial.<h4>Background</h4>Rapid development and implementation of vaccines constituted a crucial step in containing the COVID-19 pandemic. A comprehensive understanding of physiological responses to these vaccines is important to build trust in medicine.<h4>Objective</h4>This study aims to investigate temporal dynamics before and after COVID-19 vaccination in 4 physiological parameters as well as the duration of menstrual cycle phases.<h4>Methods</h4>In a prospective trial, 17,825 adults in the Netherlands wore a medical device on their wrist for up to 9 months. The device recorded their physiological signals and synchronized with a complementary smartphone app. By means of multilevel quadratic regression, we examined changes in wearable-recorded breathing rate, wrist skin temperature, heart rate2024-01-01T00:00:00Z2024 Jul2026-06-01T16:26:49.735Z2026-04-08T14:09:45.196ZS-EPMC113251103908377010.2196/51120