{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lundahl MN"],"funding":["NIGMS NIH HHS"],"pagination":["12710-12720"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11325341"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(32)"],"pubmed_abstract":["Converting triplet dioxygen into a powerful oxidant is fundamentally important to life. The study reported herein quantitatively examines the formation of a well-characterized, reactive, O<sub>2</sub>-derived thiolate ligated Fe<sup>III</sup>-superoxo using low-temperature stopped-flow kinetics. Comparison of the kinetic barriers to the formation of this species <i>via</i> two routes, involving either the addition of (a) O<sub>2</sub> to [Fe<sup>II</sup>(S<sub>2</sub> <sup>Me2</sup>N<sub>3</sub>(Pr,Pr))] (1) or (b) superoxide to [Fe<sup>III</sup>(S<sub>2</sub> <sup>Me2</sup>N<sub>3</sub>(Pr,Pr))]<sup>+</sup> (3) is shown to provide insight into the mechanism of O<sub>2</sub> activation. Route (b) was shown to be significantly slower, and the kinetic barrier 14.9 kJ mol<sup>-1</sup> higher "],"journal":["Chemical science"],"pubmed_title":["Exploring the influence of H-bonding and ligand constraints on thiolate ligated non-heme iron mediated dioxygen activation."],"pmcid":["PMC11325341"],"funding_grant_id":["R01 GM123062"],"pubmed_authors":["Kaminsky W","Kovacs JA","Piquette MC","Gannon PM","Greiner MB","Lundahl MN"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the influence of H-bonding and ligand constraints on thiolate ligated non-heme iron mediated dioxygen activation.","description":"Converting triplet dioxygen into a powerful oxidant is fundamentally important to life. The study reported herein quantitatively examines the formation of a well-characterized, reactive, O<sub>2</sub>-derived thiolate ligated Fe<sup>III</sup>-superoxo using low-temperature stopped-flow kinetics. Comparison of the kinetic barriers to the formation of this species <i>via</i> two routes, involving either the addition of (a) O<sub>2</sub> to [Fe<sup>II</sup>(S<sub>2</sub> <sup>Me2</sup>N<sub>3</sub>(Pr,Pr))] (1) or (b) superoxide to [Fe<sup>III</sup>(S<sub>2</sub> <sup>Me2</sup>N<sub>3</sub>(Pr,Pr))]<sup>+</sup> (3) is shown to provide insight into the mechanism of O<sub>2</sub> activation. Route (b) was shown to be significantly slower, and the kinetic barrier 14.9 kJ mol<sup>-1</sup> higher ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-04T02:50:23.172Z","creation":"2025-04-04T02:50:23.172Z"},"accession":"S-EPMC11325341","cross_references":{"pubmed":["39148773"],"doi":["10.1039/d4sc02787f"]}}