{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mallory MA"],"funding":["NIH/NCI Cancer Center Support Grant","NCI NIH HHS"],"pagination":["137-148"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11325477"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["194(1)"],"pubmed_abstract":["<h4>Purpose</h4>Lobular carcinoma in situ (LCIS) confers increased cancer risk in either breast, but it remains unclear if this population is at increased risk for bilateral breast cancer (BC) development. Here we report bilateral BC incidence among women with a history of LCIS.<h4>Methods</h4>Women with classic-type LCIS diagnosed from 1980 to 2017 who developed unilateral BC (UBC) or bilateral BC were identified. Bilateral BC was categorized as synchronous (bilateral BC diagnosed < 6 months apart; SBBC) or metachronous (bilateral BC diagnosed ≥ 6 months apart; MBBC). Five-year incidence rates of bilateral BC among this population were evaluated. Comparisons were made to identify factors associated with bilateral BC.<h4>Results</h4>At 7 years' median follow-up, 249/1651 (15%) women with L"],"journal":["Breast cancer research and treatment"],"pubmed_title":["Synchronous and metachronous bilateral breast cancer among women with a history of lobular carcinoma in situ."],"pmcid":["PMC11325477"],"funding_grant_id":["P30 CA008748","P30CA008748"],"pubmed_authors":["Gilbert E","Whiting K","Pilewskie ML","Park A","King TA","Gonen M","Mallory MA"],"additional_accession":[]},"is_claimable":false,"name":"Synchronous and metachronous bilateral breast cancer among women with a history of lobular carcinoma in situ.","description":"<h4>Purpose</h4>Lobular carcinoma in situ (LCIS) confers increased cancer risk in either breast, but it remains unclear if this population is at increased risk for bilateral breast cancer (BC) development. Here we report bilateral BC incidence among women with a history of LCIS.<h4>Methods</h4>Women with classic-type LCIS diagnosed from 1980 to 2017 who developed unilateral BC (UBC) or bilateral BC were identified. Bilateral BC was categorized as synchronous (bilateral BC diagnosed < 6 months apart; SBBC) or metachronous (bilateral BC diagnosed ≥ 6 months apart; MBBC). Five-year incidence rates of bilateral BC among this population were evaluated. Comparisons were made to identify factors associated with bilateral BC.<h4>Results</h4>At 7 years' median follow-up, 249/1651 (15%) women with L","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-19T14:50:16.101Z","creation":"2025-04-19T14:50:16.101Z"},"accession":"S-EPMC11325477","cross_references":{"pubmed":["35488092"],"doi":["10.1007/s10549-022-06532-4"]}}