{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen YF"],"funding":["National Taiwan University Hospital, Yun-Lin Branch, Taiwan","Ministry of Science and Technology, Taiwan"],"pagination":["308"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11325704"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Background</h4>Airflow obstruction is a hallmark of disease severity and prognosis in bronchiectasis. The relationship between lung microbiota, airway inflammation, and outcomes in bronchiectasis with fixed airflow obstruction (FAO) remains unclear. This study explores these interactions in bronchiectasis patients, with and without FAO, and compares them to those diagnosed with chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>This prospective observational study in Taiwan enrolled patients with either bronchiectasis or COPD. To analyze the lung microbiome and assess inflammatory markers, bronchoalveolar lavage (BAL) samples were collected for 16S rRNA gene sequencing. The study cohort comprised 181 patients: 86 with COPD, 46 with bronchiectasis, and 49 with bronchiectasis a"],"journal":["Respiratory research"],"pubmed_title":["The clinical impacts of lung microbiome in bronchiectasis with fixed airflow obstruction: a prospective cohort study."],"pmcid":["PMC11325704"],"funding_grant_id":["MOST 107-2314-B-002-235-MY3","NTUHYL109. X011"],"pubmed_authors":["Lu KZ","Chen YF","Chien JY","Chen CM","Chien N","Cheng SL","Liao YC","Yu CJ","Lor KL","Hsueh PR","Chen CY","Wang HC","Hou HH","Lin CH"],"additional_accession":[]},"is_claimable":false,"name":"The clinical impacts of lung microbiome in bronchiectasis with fixed airflow obstruction: a prospective cohort study.","description":"<h4>Background</h4>Airflow obstruction is a hallmark of disease severity and prognosis in bronchiectasis. The relationship between lung microbiota, airway inflammation, and outcomes in bronchiectasis with fixed airflow obstruction (FAO) remains unclear. This study explores these interactions in bronchiectasis patients, with and without FAO, and compares them to those diagnosed with chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>This prospective observational study in Taiwan enrolled patients with either bronchiectasis or COPD. To analyze the lung microbiome and assess inflammatory markers, bronchoalveolar lavage (BAL) samples were collected for 16S rRNA gene sequencing. The study cohort comprised 181 patients: 86 with COPD, 46 with bronchiectasis, and 49 with bronchiectasis a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-05-02T12:38:45.925Z","creation":"2025-04-05T10:09:31.742Z"},"accession":"S-EPMC11325704","cross_references":{"pubmed":["39143556"],"doi":["10.1186/s12931-024-02931-x"]}}