{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Paioti PHS"],"funding":["U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health","ANR","U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER)","Centre National de la Recherche Scientifique","U.S. Department of Health & Human Services | National Institutes of Health (NIH)","U.S. Department of Health & Human Services | National Institutes of Health","NIGMS NIH HHS"],"pagination":["426-436"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11326532"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(3)"],"pubmed_abstract":["The appeal of catalytic click chemistry is largely due to the copper-catalysed azide-alkyne cycloaddition (CuAAC) process, which is orthogonal to the more recently introduced sulfur-fluoride exchange (SuFEx). However, the triazole rings generated by CuAAC are not readily modifiable, and SuFEx connectors cannot be selectively functionalized, attributes that would be attractive in a click process. Here we introduce bisphosphine-copper-catalysed phenoxydiazaborinine formation (CuPDF), a link-and-in situ modify strategy for merging a nitrile, an allene, a diborane and a hydrazine. We also present copper- and palladium-catalysed quinoline formation (Cu/PdQNF), which is applicable in aqueous media, involving an aniline as the modifier. CuPDF and Cu/PdQNF are easy to perform and deliver robust, a"],"journal":["Nature chemistry"],"pubmed_title":["Click processes orthogonal to CuAAC and SuFEx forge selectively modifiable fluorescent linkers."],"pmcid":["PMC11326532"],"funding_grant_id":["130395","GM-130395","R35 GM130395"],"pubmed_authors":["Del Pozo J","Lounsbury KE","Hackey ME","Formica M","Romiti F","Bauer V","Zandonella C","Hoveyda AH","Paioti PHS"],"additional_accession":[]},"is_claimable":false,"name":"Click processes orthogonal to CuAAC and SuFEx forge selectively modifiable fluorescent linkers.","description":"The appeal of catalytic click chemistry is largely due to the copper-catalysed azide-alkyne cycloaddition (CuAAC) process, which is orthogonal to the more recently introduced sulfur-fluoride exchange (SuFEx). However, the triazole rings generated by CuAAC are not readily modifiable, and SuFEx connectors cannot be selectively functionalized, attributes that would be attractive in a click process. Here we introduce bisphosphine-copper-catalysed phenoxydiazaborinine formation (CuPDF), a link-and-in situ modify strategy for merging a nitrile, an allene, a diborane and a hydrazine. We also present copper- and palladium-catalysed quinoline formation (Cu/PdQNF), which is applicable in aqueous media, involving an aniline as the modifier. CuPDF and Cu/PdQNF are easy to perform and deliver robust, a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-18T21:20:13.634Z","creation":"2025-04-07T09:19:58.185Z"},"accession":"S-EPMC11326532","cross_references":{"pubmed":["38093093"],"doi":["10.1038/s41557-023-01386-9"]}}