{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Montelongo-Martinez LF"],"funding":["Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica (PAPIIT) DGAPA, UNAM","Consejo Nacional de Humanidades, Ciencias y Tecnologías"],"pagination":["e0307174"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11326643"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(8)"],"pubmed_abstract":["Pseudomonas aeruginosa is an opportunist bacterium that causes acute and chronic infections. During acute infections, the type III secretion system (T3SS) plays a pivotal role in allowing the bacteria to translocate effectors such as ExoS, ExoT, and ExoY into host cells for colonization. Previous research on the involvement of quorum sensing systems Las and Rhl in controlling the T3SS gene expression produced ambiguous results. In this study, we determined the role of the Las and Rhl systems and the PqsE protein on T3SS expression. Our results show that in the wild-type PAO1 strain, the deletion of lasR or pqsE do not affect the secretion of ExoS. However, rhlI inactivation increases the expression of T3SS genes. In contrast to the rhlI deletion, rhlR inactivation decreases both T3SS genes"],"journal":["PloS one"],"pubmed_title":["The quorum sensing regulator RhlR positively controls the expression of the type III secretion system in Pseudomonas aeruginosa PAO1."],"pmcid":["PMC11326643"],"funding_grant_id":["CF-53366","IN229023","IA200823","IA204221","IN201222"],"pubmed_authors":["Flores-Vega VR","Quiroz-Morales SE","Diaz-Guerrero M","Cocotl-Yanez M","Montelongo-Martinez LF","Soberon-Chavez G","Gonzalez-Pedrajo B","Rosales-Reyes R","Soto-Aceves MP"],"additional_accession":[]},"is_claimable":false,"name":"The quorum sensing regulator RhlR positively controls the expression of the type III secretion system in Pseudomonas aeruginosa PAO1.","description":"Pseudomonas aeruginosa is an opportunist bacterium that causes acute and chronic infections. During acute infections, the type III secretion system (T3SS) plays a pivotal role in allowing the bacteria to translocate effectors such as ExoS, ExoT, and ExoY into host cells for colonization. Previous research on the involvement of quorum sensing systems Las and Rhl in controlling the T3SS gene expression produced ambiguous results. In this study, we determined the role of the Las and Rhl systems and the PqsE protein on T3SS expression. Our results show that in the wild-type PAO1 strain, the deletion of lasR or pqsE do not affect the secretion of ExoS. However, rhlI inactivation increases the expression of T3SS genes. In contrast to the rhlI deletion, rhlR inactivation decreases both T3SS genes","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-21T22:06:53.679Z","creation":"2025-04-21T22:06:53.679Z"},"accession":"S-EPMC11326643","cross_references":{"pubmed":["39146292"],"doi":["10.1371/journal.pone.0307174"]}}