{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Troost JP"],"funding":["NIDDK NIH HHS","Nephcure","NIDDK"],"pagination":["2527-2536"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11328569"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(8)"],"pubmed_abstract":["<h4>Introduction</h4>Environmental contributors to kidney disease progression remain elusive. We explored how residential air pollution affects disease progression in patients with primary glomerulopathies.<h4>Methods</h4>Nephrotic Syndrome Study Network (NEPTUNE) and CureGlomerulonephropathy (CureGN) participants with residential census tract data and ≥2 years of follow-up were included. Using Cox proportional hazards models, the associations per doubling in annual average baseline concentrations of total particulate matter with diameter ≤2.5 μm (PM<sub>2.5</sub>) and its components, black carbon (BC), and sulfate, with time to ≥40% decline in estimated glomerular filtration rate (eGFR) or kidney failure were estimated. Serum tumour necrosis factor levels and kidney tissue transcriptomic "],"journal":["Kidney international reports"],"pubmed_title":["Elevated Exposure to Air Pollutants Accelerates Primary Glomerular Disease Progression."],"pmcid":["PMC11328569"],"funding_grant_id":["U01 DK100876","U24 DK100845","U54 DK083912","UM1 DK100867","UM1 DK100845","UM1 DK100846","UM1 DK100876","UM1 DK100866","U01 DK100867","U01 DK100866","U01 DK100846"],"pubmed_authors":["Engel LS","Ju W","Troost JP","Helmuth M","Eddy S","Klein J","O'Lenick CR","D'Souza J","Kretzler M","Mariani LH","Kshirsagar AV","Buxton M","Smoyer WE","Trachtman H"],"additional_accession":[]},"is_claimable":false,"name":"Elevated Exposure to Air Pollutants Accelerates Primary Glomerular Disease Progression.","description":"<h4>Introduction</h4>Environmental contributors to kidney disease progression remain elusive. We explored how residential air pollution affects disease progression in patients with primary glomerulopathies.<h4>Methods</h4>Nephrotic Syndrome Study Network (NEPTUNE) and CureGlomerulonephropathy (CureGN) participants with residential census tract data and ≥2 years of follow-up were included. Using Cox proportional hazards models, the associations per doubling in annual average baseline concentrations of total particulate matter with diameter ≤2.5 μm (PM<sub>2.5</sub>) and its components, black carbon (BC), and sulfate, with time to ≥40% decline in estimated glomerular filtration rate (eGFR) or kidney failure were estimated. Serum tumour necrosis factor levels and kidney tissue transcriptomic ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-04T00:09:06.231Z","creation":"2025-04-04T00:09:06.231Z"},"accession":"S-EPMC11328569","cross_references":{"pubmed":["39156153"],"doi":["10.1016/j.ekir.2024.05.013"]}}