biostudies-literatureTroost JPNIDDK NIH HHSNephcureNIDDK2527-2536https://www.ebi.ac.uk/biostudies/studies/S-EPMC11328569biostudies-literatureUnknown9(8)<h4>Introduction</h4>Environmental contributors to kidney disease progression remain elusive. We explored how residential air pollution affects disease progression in patients with primary glomerulopathies.<h4>Methods</h4>Nephrotic Syndrome Study Network (NEPTUNE) and CureGlomerulonephropathy (CureGN) participants with residential census tract data and ≥2 years of follow-up were included. Using Cox proportional hazards models, the associations per doubling in annual average baseline concentrations of total particulate matter with diameter ≤2.5 μm (PM_2.5) and its components, black carbon (BC), and sulfate, with time to ≥40% decline in estimated glomerular filtration rate (eGFR) or kidney failure were estimated. Serum tumour necrosis factor levels and kidney tissue transcriptomic Kidney international reportsElevated Exposure to Air Pollutants Accelerates Primary Glomerular Disease Progression.PMC11328569U01 DK100876U24 DK100845U54 DK083912UM1 DK100867UM1 DK100845UM1 DK100846UM1 DK100876UM1 DK100866U01 DK100867U01 DK100866U01 DK100846Engel LSJu WTroost JPHelmuth MEddy SKlein JO'Lenick CRD'Souza JKretzler MMariani LHKshirsagar AVBuxton MSmoyer WETrachtman HfalseElevated Exposure to Air Pollutants Accelerates Primary Glomerular Disease Progression.<h4>Introduction</h4>Environmental contributors to kidney disease progression remain elusive. We explored how residential air pollution affects disease progression in patients with primary glomerulopathies.<h4>Methods</h4>Nephrotic Syndrome Study Network (NEPTUNE) and CureGlomerulonephropathy (CureGN) participants with residential census tract data and ≥2 years of follow-up were included. Using Cox proportional hazards models, the associations per doubling in annual average baseline concentrations of total particulate matter with diameter ≤2.5 μm (PM_2.5) and its components, black carbon (BC), and sulfate, with time to ≥40% decline in estimated glomerular filtration rate (eGFR) or kidney failure were estimated. Serum tumour necrosis factor levels and kidney tissue transcriptomic 2024-01-01T00:00:00Z2024 Aug2025-04-04T00:09:06.231Z2025-04-04T00:09:06.231ZS-EPMC113285693915615310.1016/j.ekir.2024.05.013