{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["397(8)"],"submitter":["Mahmoud SA"],"funding":["Helwan University"],"pubmed_abstract":["Gastric ulcer is a disturbing disease that impacts many people worldwide. Pioglitazone (Piog), a thiazolidinedione, and ligustrazine (Ligu), a natural component of Ligusticum chuanxiong possess gastroprotective properties. However, the underlying mechanism is not well elucidated. The present study aimed to investigate the gastroprotective effects of Piog (15 mg/kg, p.o.), Ligu (15 mg/kg, p.o.), and their combination against ethanol-induced gastric ulcer in rats. Omeprazole (10 mg/kg) was used as a standard. Pre-treatment for 7 days with Piog, Ligu, and (Piog+Ligu) effectively alleviated ethanol-predisposed oxidative stress and inflammation through restoring HO-1, GSH, and SOD tissue levels and decreasing elevated MDA, TNF-α, ICAM, I-NOS, and IL-1β contents. Moreover, Piog, Ligu, and (Piog+"],"journal":["Naunyn-Schmiedeberg's archives of pharmacology"],"pagination":["6177-6195"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11329587"],"repository":["biostudies-literature"],"pubmed_title":["Enhanced upregulation of SIRT1 via pioglitazone and ligustrazine confers protection against ethanol-induced gastric ulcer in rats."],"pmcid":["PMC11329587"],"pubmed_authors":["Ahmed AAE","Elkhoely A","Mahmoud SA","El-Sayed EK"],"additional_accession":[]},"is_claimable":false,"name":"Enhanced upregulation of SIRT1 via pioglitazone and ligustrazine confers protection against ethanol-induced gastric ulcer in rats.","description":"Gastric ulcer is a disturbing disease that impacts many people worldwide. Pioglitazone (Piog), a thiazolidinedione, and ligustrazine (Ligu), a natural component of Ligusticum chuanxiong possess gastroprotective properties. However, the underlying mechanism is not well elucidated. The present study aimed to investigate the gastroprotective effects of Piog (15 mg/kg, p.o.), Ligu (15 mg/kg, p.o.), and their combination against ethanol-induced gastric ulcer in rats. Omeprazole (10 mg/kg) was used as a standard. Pre-treatment for 7 days with Piog, Ligu, and (Piog+Ligu) effectively alleviated ethanol-predisposed oxidative stress and inflammation through restoring HO-1, GSH, and SOD tissue levels and decreasing elevated MDA, TNF-α, ICAM, I-NOS, and IL-1β contents. Moreover, Piog, Ligu, and (Piog+","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-21T22:06:13.485Z","creation":"2025-04-05T18:37:01.399Z"},"accession":"S-EPMC11329587","cross_references":{"pubmed":["38441571"],"doi":["10.1007/s00210-024-03026-6"]}}