{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang GS"],"funding":["National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["2256-2270"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11331041"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["123(15)"],"pubmed_abstract":["Interleaflet coupling-the influence of one leaflet on the properties of the opposing leaflet-is a fundamental plasma membrane organizational principle. This coupling is proposed to participate in maintaining steady-state biophysical properties of the plasma membrane, which in turn regulates some transmembrane signaling processes. A prominent example is antigen (Ag) stimulation of signaling by clustering transmembrane receptors for immunoglobulin E (IgE), FcεRI. This transmembrane signaling depends on the stabilization of ordered regions in the inner leaflet for sorting of intracellular signaling components. The resting inner leaflet has a lipid composition that is generally less ordered than the outer leaflet and that does not spontaneously phase separate in model membranes. We propose tha"],"journal":["Biophysical journal"],"pubmed_title":["Lipid-driven interleaflet coupling of plasma membrane order regulates FcεRI signaling in mast cells."],"pmcid":["PMC11331041"],"funding_grant_id":["R35GM122493","R01GM117552","R01 GM117552","R35 GM122493"],"pubmed_authors":["Suresh P","Yang GS","Wagenknecht-Wiesner A","Yin B","Baird BA","Bag N","London E"],"additional_accession":[]},"is_claimable":false,"name":"Lipid-driven interleaflet coupling of plasma membrane order regulates FcεRI signaling in mast cells.","description":"Interleaflet coupling-the influence of one leaflet on the properties of the opposing leaflet-is a fundamental plasma membrane organizational principle. This coupling is proposed to participate in maintaining steady-state biophysical properties of the plasma membrane, which in turn regulates some transmembrane signaling processes. A prominent example is antigen (Ag) stimulation of signaling by clustering transmembrane receptors for immunoglobulin E (IgE), FcεRI. This transmembrane signaling depends on the stabilization of ordered regions in the inner leaflet for sorting of intracellular signaling components. The resting inner leaflet has a lipid composition that is generally less ordered than the outer leaflet and that does not spontaneously phase separate in model membranes. We propose tha","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-03-27T17:14:20.287Z","creation":"2025-08-30T03:09:55.446Z"},"accession":"S-EPMC11331041","cross_references":{"pubmed":["37533258"],"doi":["10.1016/j.bpj.2023.07.027"]}}