{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Diercks AH"],"funding":["NIAID NIH HHS","HHS | NIH","HHS | NIH (NIH)"],"pagination":["e2406492121"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11331125"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(33)"],"pubmed_abstract":["Toll-like receptors (TLRs) on macrophages sense microbial components and trigger the production of numerous cytokines and chemokines that mediate the inflammatory response to infection. Although many of the components required for the activation of the TLR pathway have been identified, the mechanisms that appropriately regulate the magnitude and duration of the response and ultimately restore homeostasis are less well understood. Furthermore, a growing body of work indicates that TLR signaling reciprocally interacts with other fundamental cellular processes, including lipid metabolism but only a few specific molecular links between immune signaling and the macrophage lipidome have been studied in detail. Oxysterol-binding protein (Osbp) is the founding member of a family of lipid-binding p"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages."],"pmcid":["PMC11331125"],"funding_grant_id":["U19 AI100627","R01AI032972","U19 AI135976","U19AI135976","U19AI100627","R01 AI032972"],"pubmed_authors":["Murray TA","Shimano H","Mai D","Aderem A","Amon LM","Diercks AH","Podolskaia IS","Gold ES","Liu D","Nakagawa Y","Jahn AN"],"additional_accession":[]},"is_claimable":false,"name":"Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages.","description":"Toll-like receptors (TLRs) on macrophages sense microbial components and trigger the production of numerous cytokines and chemokines that mediate the inflammatory response to infection. Although many of the components required for the activation of the TLR pathway have been identified, the mechanisms that appropriately regulate the magnitude and duration of the response and ultimately restore homeostasis are less well understood. Furthermore, a growing body of work indicates that TLR signaling reciprocally interacts with other fundamental cellular processes, including lipid metabolism but only a few specific molecular links between immune signaling and the macrophage lipidome have been studied in detail. Oxysterol-binding protein (Osbp) is the founding member of a family of lipid-binding p","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-02T10:16:10.323Z","creation":"2025-04-19T06:01:21.925Z"},"accession":"S-EPMC11331125","cross_references":{"pubmed":["39361877"],"doi":["10.1073/pnas.2406492121"]}}