{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ferguson AA"],"funding":["NIAID NIH HHS","NCI NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["e13056"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11331508"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(7)"],"pubmed_abstract":["Co-evolutionary adaptation of hookworms with their mammalian hosts has been selected for immunoregulatory excretory/secretory (E/S) products. However, it is not known whether, or if so, how host immunological status impacts the secreted profile of hematophagous adult worms. This study interrogated the impact of host Signal transducer and activator of transcription 6 (STAT6) expression during the experimental evolution of hookworms through the sequential passage of the life cycle in either STAT6 deficient or WT C57BL/6 mice. Proteomic analysis of E/S products by LC-MS showed increased abundance of 15 proteins, including myosin-3, related to muscle function, and aconitate hydratase, related to iron homeostasis. However, most E/S proteins (174 of 337 unique identities) were decreased, includi"],"journal":["Parasite immunology"],"pubmed_title":["The Secretome of Adult Murine Hookworms Is Shaped by Host Expression of STAT6."],"pmcid":["PMC11331508"],"funding_grant_id":["R01 AI050668","T32‐AI007532","R21 AI171740","U01AI163062","R01-AI050668","P30 CA010815","R01AI164715","R01 AI164715","R01‐AI050668","T32 AI007532","U01 AI163062","T32-AI007532"],"pubmed_authors":["Herbert DR","Ferguson AA","Rossi HL"],"additional_accession":[]},"is_claimable":false,"name":"The Secretome of Adult Murine Hookworms Is Shaped by Host Expression of STAT6.","description":"Co-evolutionary adaptation of hookworms with their mammalian hosts has been selected for immunoregulatory excretory/secretory (E/S) products. However, it is not known whether, or if so, how host immunological status impacts the secreted profile of hematophagous adult worms. This study interrogated the impact of host Signal transducer and activator of transcription 6 (STAT6) expression during the experimental evolution of hookworms through the sequential passage of the life cycle in either STAT6 deficient or WT C57BL/6 mice. Proteomic analysis of E/S products by LC-MS showed increased abundance of 15 proteins, including myosin-3, related to muscle function, and aconitate hydratase, related to iron homeostasis. However, most E/S proteins (174 of 337 unique identities) were decreased, includi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-05-26T11:07:35.853Z","creation":"2026-05-24T03:07:15.048Z"},"accession":"S-EPMC11331508","cross_references":{"pubmed":["39073185"],"doi":["10.1111/pim.13056"]}}