{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang L"],"funding":["National Natural Science Foundation of China for Young Scholars"],"pagination":["111"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11334498"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(1)"],"pubmed_abstract":["<h4>Objective</h4>Colorectal cancer (CRC) is a form of malignancy that exhibits a comparatively elevated occurrence and fatality rate. Given the relatively slower progress in diagnostic and therapeutic approaches for CRC, there is a need to investigate more accurate and efficient biomarkers.<h4>Methods</h4>Core regulatory genes were screened using the TCGA database, and the expression of neurexophilin 4 (NXPH4) and its prognostic implications were validated using tissue microarray staining. The assessment of NXPH4 functions involved a range of experiments, including cellular, organoid, and murine models. Furthermore, a regulatory network between m<sup>5</sup>C, NXPH4, and HIF1A was established through several in vitro experiments.<h4>Results</h4>The overexpression of NXPH4 is associated wi"],"journal":["Cellular & molecular biology letters"],"pubmed_title":["NXPH4 mediated by m<sup>5</sup>C contributes to the malignant characteristics of colorectal cancer via inhibiting HIF1A degradation."],"pmcid":["PMC11334498"],"funding_grant_id":["82303877"],"pubmed_authors":["Xu L","Lian Z","Yang L","Huang J","He G","Xu H","Wu H","Miao K","Yin H","Sun P","Zhang X","Shi J","Wang Z","Zhong M"],"additional_accession":[]},"is_claimable":false,"name":"NXPH4 mediated by m<sup>5</sup>C contributes to the malignant characteristics of colorectal cancer via inhibiting HIF1A degradation.","description":"<h4>Objective</h4>Colorectal cancer (CRC) is a form of malignancy that exhibits a comparatively elevated occurrence and fatality rate. Given the relatively slower progress in diagnostic and therapeutic approaches for CRC, there is a need to investigate more accurate and efficient biomarkers.<h4>Methods</h4>Core regulatory genes were screened using the TCGA database, and the expression of neurexophilin 4 (NXPH4) and its prognostic implications were validated using tissue microarray staining. The assessment of NXPH4 functions involved a range of experiments, including cellular, organoid, and murine models. Furthermore, a regulatory network between m<sup>5</sup>C, NXPH4, and HIF1A was established through several in vitro experiments.<h4>Results</h4>The overexpression of NXPH4 is associated wi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-03T01:00:17.105Z","creation":"2024-10-18T19:42:10.299Z"},"accession":"S-EPMC11334498","cross_references":{"pubmed":["39164641"],"doi":["10.1186/s11658-024-00630-5"]}}