{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cai M"],"funding":["National Key Clinical Specialty Discipline Construction Program of China","Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission"],"pagination":["e0309136"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11335095"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(8)"],"pubmed_abstract":["<h4>Background</h4>Postoperative nausea and vomiting are common complications after surgery, and female patients are more likely to experience these adverse events. The goal of this study was to explore the relationship between the CHRM3 rs2165870 polymorphism and postoperative vomiting incidence in female patients who underwent laparoscopic surgery.<h4>Methods</h4>Two hundred female patients who underwent elective laparoscopic surgery with subsequent patient-controlled intravenous analgesia using dexmedetomidine and sufentanil were prospectively enrolled. The CHRM3 rs2165870 and KCNB2 rs349358 polymorphisms were genotyped using MassARRAY SNP typing technology. Demographic data and preoperative laboratory results of all patients were recorded. Postoperative analgesia-related information, i"],"journal":["PloS one"],"pubmed_title":["CHRM3 (rs2165870) gene polymorphism is related to postoperative vomiting in female patients undergoing laparoscopic surgery. Prospective observational study."],"pmcid":["PMC11335095"],"funding_grant_id":["cstc2021jcyj-msxmX0763","Obstetrics and Gynecology"],"pubmed_authors":["Li J","Cai M","Gan L","Lei X","Yu J"],"additional_accession":[]},"is_claimable":false,"name":"CHRM3 (rs2165870) gene polymorphism is related to postoperative vomiting in female patients undergoing laparoscopic surgery. Prospective observational study.","description":"<h4>Background</h4>Postoperative nausea and vomiting are common complications after surgery, and female patients are more likely to experience these adverse events. The goal of this study was to explore the relationship between the CHRM3 rs2165870 polymorphism and postoperative vomiting incidence in female patients who underwent laparoscopic surgery.<h4>Methods</h4>Two hundred female patients who underwent elective laparoscopic surgery with subsequent patient-controlled intravenous analgesia using dexmedetomidine and sufentanil were prospectively enrolled. The CHRM3 rs2165870 and KCNB2 rs349358 polymorphisms were genotyped using MassARRAY SNP typing technology. Demographic data and preoperative laboratory results of all patients were recorded. Postoperative analgesia-related information, i","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-02T04:47:18.051Z","creation":"2025-05-18T12:13:17.539Z"},"accession":"S-EPMC11335095","cross_references":{"pubmed":["39163289"],"doi":["10.1371/journal.pone.0309136"]}}