biostudies-literatureZhang YKey Technologies Research and Development ProgramNatural Science Foundation of Tianjin MunicipalityNational Natural Science Foundation of China264https://www.ebi.ac.uk/biostudies/studies/S-EPMC11335301biostudies-literatureUnknown81(1)Atrial fibrillation (AF) is the most common arrhythmia, and atrial fibrosis is a pathological hallmark of structural remodeling in AF. Prostaglandin I<sub>2</sub> (PGI<sub>2</sub>) can prevent the process of fibrosis in various tissues via cell surface Prostaglandin I<sub>2</sub> receptor (IP). However, the role of PGI<sub>2</sub> in AF and atrial fibrosis remains unclear. The present study aimed to clarify the role of PGI<sub>2</sub> in angiotensin II (Ang II)-induced AF and the underlying molecular mechanism. PGI<sub>2</sub> content was decreased in both plasma and atrial tissue from patients with AF and mice treated with Ang II. Treatment with the PGI<sub>2</sub> analog, iloprost, reduced Ang II-induced AF and atrial fibrosis. Iloprost prevented Ang II-induced atrial fibroblast collagenCellular and molecular life sciences : CMLSProstaglandin I<sub>2</sub> signaling prevents angiotensin II-induced atrial remodeling and vulnerability to atrial fibrillation in mice.PMC1133530118JCQNJC8260082000272818002972020YFA0803703Li GZhu YYuan MSun WYan YLiu TShi XBao QZhang YZhang XLiu DSong WZhang BCai WChen TfalseProstaglandin I<sub>2</sub> signaling prevents angiotensin II-induced atrial remodeling and vulnerability to atrial fibrillation in mice.Atrial fibrillation (AF) is the most common arrhythmia, and atrial fibrosis is a pathological hallmark of structural remodeling in AF. Prostaglandin I<sub>2</sub> (PGI<sub>2</sub>) can prevent the process of fibrosis in various tissues via cell surface Prostaglandin I<sub>2</sub> receptor (IP). However, the role of PGI<sub>2</sub> in AF and atrial fibrosis remains unclear. The present study aimed to clarify the role of PGI<sub>2</sub> in angiotensin II (Ang II)-induced AF and the underlying molecular mechanism. PGI<sub>2</sub> content was decreased in both plasma and atrial tissue from patients with AF and mice treated with Ang II. Treatment with the PGI<sub>2</sub> analog, iloprost, reduced Ang II-induced AF and atrial fibrosis. Iloprost prevented Ang II-induced atrial fibroblast collagen2024-01-01T00:00:00Z2024 Jun2025-04-26T21:22:55.014Z2025-04-06T16:45:19.249ZS-EPMC113353013887821410.1007/s00018-024-05259-3