{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma X"],"funding":["Science and Technology Plan Project of Jiangsu Provincial","Shandong Provincial Natural Science Foundation","Natural Science Foundation of Shandong Province","National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["e2400726"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11336902"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(31)"],"pubmed_abstract":["Epigenetic mechanisms such as DNA methylation and hydroxymethylation play a significant role in depression. This research has shown that Ten-eleven translocation 2 (Tet2) deficiency prompts depression-like behaviors, but Tet2's transcriptional regulation remains unclear. In the study, bioinformatics is used to identify nuclear receptor subfamily 2 group E member 3 (Nr2e3) as a potential Tet2 regulator. Nr2e3 is found to enhance Tet2's transcriptional activity by binding to its promoter region. Nr2e3 knockdown in mouse hippocampus leads to reduced Tet2 expression, depression-like behaviors, decreased hydroxymethylation of synaptic genes, and downregulation of synaptic proteins like postsynaptic density 95 KDa (PSD95) and N-methy-d-aspartate receptor 1 (NMDAR1). Fewer dendritic spines are al"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Targeting Nr2e3 to Modulate Tet2 Expression: Therapeutic Potential for Depression Treatment."],"pmcid":["PMC11336902"],"funding_grant_id":["82071511","2017YFE0103700","ZR2019ZD32","BE2023700"],"pubmed_authors":["Yang H","Wan B","Yang Y","Ma X","Xu S","Zhou Y","Xu X","Zhang Q","Miao Z"],"additional_accession":[]},"is_claimable":false,"name":"Targeting Nr2e3 to Modulate Tet2 Expression: Therapeutic Potential for Depression Treatment.","description":"Epigenetic mechanisms such as DNA methylation and hydroxymethylation play a significant role in depression. This research has shown that Ten-eleven translocation 2 (Tet2) deficiency prompts depression-like behaviors, but Tet2's transcriptional regulation remains unclear. In the study, bioinformatics is used to identify nuclear receptor subfamily 2 group E member 3 (Nr2e3) as a potential Tet2 regulator. Nr2e3 is found to enhance Tet2's transcriptional activity by binding to its promoter region. Nr2e3 knockdown in mouse hippocampus leads to reduced Tet2 expression, depression-like behaviors, decreased hydroxymethylation of synaptic genes, and downregulation of synaptic proteins like postsynaptic density 95 KDa (PSD95) and N-methy-d-aspartate receptor 1 (NMDAR1). Fewer dendritic spines are al","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-04T07:55:35.068Z","creation":"2024-11-07T06:50:34.591Z"},"accession":"S-EPMC11336902","cross_references":{"pubmed":["38881534"],"doi":["10.1002/advs.202400726"]}}