{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["40"],"submitter":["Taylor JA"],"funding":["US Department of Defense"],"pubmed_abstract":["Recently, the diagnosis of autism spectrum disorder (ASD) has increased from 1 in 150 to every 1 in 36 children in the United States, warranting a need for novel prevention and therapeutic strategies. Broad-spectrum cannabidiol oil, free from delta-9-tetrahydrocannabinol, the psychoactive component of cannabis, may be one such therapeutic. It has a high safety profile and is frequently used as a complementary and integrative intervention by persons experiencing symptoms of anxiety, stress, and inflammation. Using a neurodevelopmental rat model of ASD (based on neuroinflammation induced by stress and terbutaline exposure during pre- and postnatal development), we sought to prevent the development of ASD-like behaviors in male offspring by administering broad-spectrum cannabidiol oil to dams"],"journal":["Brain, behavior, & immunity - health"],"pagination":["100828"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11337682"],"repository":["biostudies-literature"],"pubmed_title":["Prenatal broad-spectrum cannabidiol administration prevents an autism-like phenotype in male offspring from a maternal stress/terbutaline rat model."],"pmcid":["PMC11337682"],"pubmed_authors":["Taylor JA","Smith ZZ","Lowry CA","Reuter JD","Holbrook EM","Barth DS","Anderson ME","Elkinbard IS"],"additional_accession":[]},"is_claimable":false,"name":"Prenatal broad-spectrum cannabidiol administration prevents an autism-like phenotype in male offspring from a maternal stress/terbutaline rat model.","description":"Recently, the diagnosis of autism spectrum disorder (ASD) has increased from 1 in 150 to every 1 in 36 children in the United States, warranting a need for novel prevention and therapeutic strategies. Broad-spectrum cannabidiol oil, free from delta-9-tetrahydrocannabinol, the psychoactive component of cannabis, may be one such therapeutic. It has a high safety profile and is frequently used as a complementary and integrative intervention by persons experiencing symptoms of anxiety, stress, and inflammation. Using a neurodevelopmental rat model of ASD (based on neuroinflammation induced by stress and terbutaline exposure during pre- and postnatal development), we sought to prevent the development of ASD-like behaviors in male offspring by administering broad-spectrum cannabidiol oil to dams","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T03:09:57.24Z","creation":"2025-04-04T03:09:57.24Z"},"accession":"S-EPMC11337682","cross_references":{"pubmed":["39170798"],"doi":["10.1016/j.bbih.2024.100828"]}}