biostudies-literatureNelson GWFrederick National Laboratory for Cancer ResearchNIAID NIH HHSNHLBI NIH HHSNCI NIH HHSe0028124https://www.ebi.ac.uk/biostudies/studies/S-EPMC11338073biostudies-literatureUnknown98(8)<i>HLA</i> class I variation has the strongest effect genome-wide on outcome after HIV infection, and as such, an understanding of the impact of <i>HLA</i> polymorphism on response to HIV vaccination may inform vaccine design. We sought <i>HLA</i> associations with HIV-directed immunogenicity in the phase 1/2a APPROACH vaccine trial, which tested vaccine regimens containing mosaic inserts in Ad26 and MVA vectors, with or without a trimeric gp140 protein. While there were no <i>HLA</i> allelic associations with the overall cellular immune response to the vaccine assessed by ELISpot (Gag, Pol, and Env combined), significant associations with differential response to Gag compared to Env antigens were observed. Notably, <i>HLA</i> class I alleles known to associate with disease susceptibility Journal of virologyPrediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles.PMC11338073U01 HL146240UM1 AI06863675N91019D00024UM1 AI068618Stieh DPau MGBarouch DHLavreys LDeRosa SCCarrington MNelson GWYuki YKirk GDWolinsky STomaka FWalker Bvan Duijn JHaas DWMichael NLMcElrath MJDeeks SGfalsePrediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles.<i>HLA</i> class I variation has the strongest effect genome-wide on outcome after HIV infection, and as such, an understanding of the impact of <i>HLA</i> polymorphism on response to HIV vaccination may inform vaccine design. We sought <i>HLA</i> associations with HIV-directed immunogenicity in the phase 1/2a APPROACH vaccine trial, which tested vaccine regimens containing mosaic inserts in Ad26 and MVA vectors, with or without a trimeric gp140 protein. While there were no <i>HLA</i> allelic associations with the overall cellular immune response to the vaccine assessed by ELISpot (Gag, Pol, and Env combined), significant associations with differential response to Gag compared to Env antigens were observed. Notably, <i>HLA</i> class I alleles known to associate with disease susceptibility 2024-01-01T00:00:00Z2024 Aug2026-06-02T23:30:31.024Z2025-04-04T03:10:41.137ZS-EPMC113380733904626310.1128/jvi.00281-24