biostudies-literatureUnknownGross RSNIDA NIH HHSNIAID NIH HHSNHLBI NIH HHS<h4>Importance</h4>Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed to characterize pediatric PASC to enable studies of underlying mechanisms that will guide future treatment.<h4>Objective</h4>To identify the most common prolonged symptoms experienced by children (aged 6 to 17 years) after SARS-CoV-2 infection, how these symptoms differ by age (school-age [6-11 years] vs adolescents [12-17 years]), how they cluster into distinct phenotypes, and what symptoms in combination could be used as an empirically derived index to assist researchers to study the likely presence of PASC.<h4>Design, setting, and participants</h4>Multicenter longitudinal obserJAMAhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC11339705biostudies-literatureCharacterizing Long COVID in Children and Adolescents.PMC11339705R01 HL162373U01 DA041120U01 DA041156U24 DA041147OT2 HL161841K23 AI159518Artis DCaldera CLimia JSabati AZaretsky JFagatele LLinas BWilensky RKrishnamoorthy ACapone CCruz Irving AShakti DTroxel AGarcia-Soberanez NHines DManning BSembajwe RChan 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ABishof KBalaraman VRoman PQuiner CAtchley-Challenner RBurton PMisra NPark HKerr JDCline KChurch RPark SSoto DMendis MRicciardi EUddin LQRosolowski BArchuleta DJohannsen RBainton JAbella JBanerjee DShemwell SFigliomeni JKwak JBaroni AKing SThomassie AMerlino AAhirwar SNolan SBenjamin DCiriello MCampbell RNguyen KPayne RMMesser ZThomason MHeitzeg MMMacFadden DHolmes VBuchbinder NCGiorgio TNguyen CPant DKleinman LMoghadam NCerkovnik STeufel RJNewburger JWfalseCharacterizing Long COVID in Children and Adolescents.<h4>Importance</h4>Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed to characterize pediatric PASC to enable studies of underlying mechanisms that will guide future treatment.<h4>Objective</h4>To identify the most common prolonged symptoms experienced by children (aged 6 to 17 years) after SARS-CoV-2 infection, how these symptoms differ by age (school-age [6-11 years] vs adolescents [12-17 years]), how they cluster into distinct phenotypes, and what symptoms in combination could be used as an empirically derived index to assist researchers to study the likely presence of PASC.<h4>Design, setting, and participants</h4>Multicenter longitudinal obser2024-01-01T00:00:00Z2024 Aug2025-04-03T23:56:08.574Z2025-04-03T23:56:08.574ZS-EPMC113397053919696410.1001/jama.2024.12747