{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen Q"],"funding":["MOST | National Natural Science Foundation of China (NSFC)","MOST | National Natural Science Foundation of China"],"pagination":["e0017824"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11340313"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["206(8)"],"pubmed_abstract":["Ciprofloxacin-resistant <i>Salmonella</i> Typhimurium (<i>S.</i> Typhimurium) causes a significant health burden worldwide. A wealth of studies has been published on the contributions of different mechanisms to ciprofloxacin resistance in <i>Salmonella</i> spp. But we still lack a deep understanding of the physiological responses and genetic changes that underlie ciprofloxacin exposure. This study aims to know how phenotypic and genotypic characteristics are impacted by ciprofloxacin exposure, from ciprofloxacin-susceptible to ciprofloxacin-resistant strains <i>in vitro</i>. Here, we investigated the multistep evolution of resistance in replicate populations of <i>S.</i> Typhimurium during 24 days of continuously increasing ciprofloxacin exposure and assessed how ciprofloxacin impacts phys"],"journal":["Journal of bacteriology"],"pubmed_title":["<i>Salmonella</i> Typhimurium alters galactitol metabolism under ciprofloxacin treatment to balance resistance and virulence."],"pmcid":["PMC11340313"],"funding_grant_id":["32172857","31602087"],"pubmed_authors":["Chen Q","Li C","Liu M","Liu D","Quan H","Gong X","Yu Y","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"<i>Salmonella</i> Typhimurium alters galactitol metabolism under ciprofloxacin treatment to balance resistance and virulence.","description":"Ciprofloxacin-resistant <i>Salmonella</i> Typhimurium (<i>S.</i> Typhimurium) causes a significant health burden worldwide. A wealth of studies has been published on the contributions of different mechanisms to ciprofloxacin resistance in <i>Salmonella</i> spp. But we still lack a deep understanding of the physiological responses and genetic changes that underlie ciprofloxacin exposure. This study aims to know how phenotypic and genotypic characteristics are impacted by ciprofloxacin exposure, from ciprofloxacin-susceptible to ciprofloxacin-resistant strains <i>in vitro</i>. Here, we investigated the multistep evolution of resistance in replicate populations of <i>S.</i> Typhimurium during 24 days of continuously increasing ciprofloxacin exposure and assessed how ciprofloxacin impacts phys","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-01T05:46:26.802Z","creation":"2025-04-05T19:19:20.011Z"},"accession":"S-EPMC11340313","cross_references":{"pubmed":["39082861"],"doi":["10.1128/jb.00178-24"]}}