{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vuerich M"],"funding":["NIDDK NIH HHS"],"pagination":["1429736"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11345147"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Extracellular ATP and its derivates mediate a signaling pathway that might be pharmacologically targeted to treat inflammatory conditions. Extracellular adenosine, the product of ATP hydrolysis by ectonucleotidase enzymes, plays a key role in halting inflammation while promoting immune tolerance. The rate-limiting ectoenzyme ENTPD1/CD39 and the ecto-5'-nucleotidase/CD73 are the prototype members of the ectonucleotidase family, being responsible for ATP degradation into immunosuppressive adenosine. The biological effects of adenosine are mediated via adenosine receptors, a family of G protein-coupled receptors largely expressed on immune cells where they modulate innate and adaptive immune responses. Inflammatory bowel disease (IBD) is a serious inflammatory condition of the gastrointestina"],"journal":["Frontiers in cell and developmental biology"],"pubmed_title":["Adenosine-mediated immune responses in inflammatory bowel disease."],"pmcid":["PMC11345147"],"funding_grant_id":["R01 DK124408"],"pubmed_authors":["Longhi MS","Vuerich M","Ferrari D","Nguyen DH"],"additional_accession":[]},"is_claimable":false,"name":"Adenosine-mediated immune responses in inflammatory bowel disease.","description":"Extracellular ATP and its derivates mediate a signaling pathway that might be pharmacologically targeted to treat inflammatory conditions. Extracellular adenosine, the product of ATP hydrolysis by ectonucleotidase enzymes, plays a key role in halting inflammation while promoting immune tolerance. The rate-limiting ectoenzyme ENTPD1/CD39 and the ecto-5'-nucleotidase/CD73 are the prototype members of the ectonucleotidase family, being responsible for ATP degradation into immunosuppressive adenosine. The biological effects of adenosine are mediated via adenosine receptors, a family of G protein-coupled receptors largely expressed on immune cells where they modulate innate and adaptive immune responses. Inflammatory bowel disease (IBD) is a serious inflammatory condition of the gastrointestina","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-18T16:52:54.044Z","creation":"2025-04-07T04:19:25.992Z"},"accession":"S-EPMC11345147","cross_references":{"pubmed":["39188525"],"doi":["10.3389/fcell.2024.1429736"]}}