biostudies-literatureVuerich MNIDDK NIH HHS1429736https://www.ebi.ac.uk/biostudies/studies/S-EPMC11345147biostudies-literatureUnknown12Extracellular ATP and its derivates mediate a signaling pathway that might be pharmacologically targeted to treat inflammatory conditions. Extracellular adenosine, the product of ATP hydrolysis by ectonucleotidase enzymes, plays a key role in halting inflammation while promoting immune tolerance. The rate-limiting ectoenzyme ENTPD1/CD39 and the ecto-5'-nucleotidase/CD73 are the prototype members of the ectonucleotidase family, being responsible for ATP degradation into immunosuppressive adenosine. The biological effects of adenosine are mediated via adenosine receptors, a family of G protein-coupled receptors largely expressed on immune cells where they modulate innate and adaptive immune responses. Inflammatory bowel disease (IBD) is a serious inflammatory condition of the gastrointestinaFrontiers in cell and developmental biologyAdenosine-mediated immune responses in inflammatory bowel disease.PMC11345147R01 DK124408Longhi MSVuerich MFerrari DNguyen DHfalseAdenosine-mediated immune responses in inflammatory bowel disease.Extracellular ATP and its derivates mediate a signaling pathway that might be pharmacologically targeted to treat inflammatory conditions. Extracellular adenosine, the product of ATP hydrolysis by ectonucleotidase enzymes, plays a key role in halting inflammation while promoting immune tolerance. The rate-limiting ectoenzyme ENTPD1/CD39 and the ecto-5'-nucleotidase/CD73 are the prototype members of the ectonucleotidase family, being responsible for ATP degradation into immunosuppressive adenosine. The biological effects of adenosine are mediated via adenosine receptors, a family of G protein-coupled receptors largely expressed on immune cells where they modulate innate and adaptive immune responses. Inflammatory bowel disease (IBD) is a serious inflammatory condition of the gastrointestina2024-01-01T00:00:00Z20242025-04-18T16:52:54.044Z2025-04-07T04:19:25.992ZS-EPMC113451473918852510.3389/fcell.2024.1429736