{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["48"],"submitter":["Wu B"],"pubmed_abstract":["<h4>Background</h4>Fibrovascular scar healing of bone-tendon interface (BTI) instead of functional fibrocartilage regeneration is the main concern associated with unsatisfactory prognosis in rotator cuff repair. Mesenchymal stem cells (MSCs) exosomes have been reported to be a new promising cell-free approach for rotator cuff healing. Whereas, controversies abound in whether exosomes of native MSCs alone can effectively induce chondrogenesis.<h4>Purpose</h4>To explore the effect of exosomes derived from low-intensity pulsed ultrasound stimulation (LIPUS)-preconditioned bone marrow mesenchymal stem cells (LIPUS-BMSC-Exos) or un-preconditioned BMSCs (BMSC-Exos) on rotator cuff healing and the underlying mechanism.<h4>Methods</h4>C57BL/6 mice underwent unilateral supraspinatus tendon detachme"],"journal":["Journal of orthopaedic translation"],"pagination":["89-106"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11345897"],"repository":["biostudies-literature"],"pubmed_title":["Exosomes derived from bone marrow mesenchymal stem cell preconditioned by low-intensity pulsed ultrasound stimulation promote bone-tendon interface fibrocartilage regeneration and ameliorate rotator cuff fatty infiltration."],"pmcid":["PMC11345897"],"pubmed_authors":["Zhang T","Hu J","Lu H","Guan C","Wu B","Chen H","Shi X"],"additional_accession":[]},"is_claimable":false,"name":"Exosomes derived from bone marrow mesenchymal stem cell preconditioned by low-intensity pulsed ultrasound stimulation promote bone-tendon interface fibrocartilage regeneration and ameliorate rotator cuff fatty infiltration.","description":"<h4>Background</h4>Fibrovascular scar healing of bone-tendon interface (BTI) instead of functional fibrocartilage regeneration is the main concern associated with unsatisfactory prognosis in rotator cuff repair. Mesenchymal stem cells (MSCs) exosomes have been reported to be a new promising cell-free approach for rotator cuff healing. Whereas, controversies abound in whether exosomes of native MSCs alone can effectively induce chondrogenesis.<h4>Purpose</h4>To explore the effect of exosomes derived from low-intensity pulsed ultrasound stimulation (LIPUS)-preconditioned bone marrow mesenchymal stem cells (LIPUS-BMSC-Exos) or un-preconditioned BMSCs (BMSC-Exos) on rotator cuff healing and the underlying mechanism.<h4>Methods</h4>C57BL/6 mice underwent unilateral supraspinatus tendon detachme","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-18T16:54:22.187Z","creation":"2025-04-07T04:20:57.795Z"},"accession":"S-EPMC11345897","cross_references":{"pubmed":["39189009"],"doi":["10.1016/j.jot.2024.07.009"]}}