biostudies-literatureUnknown15Chen MH<h4>Objective</h4>Psilocybin-assisted therapy has shown promising efficacy on clinical depressive symptoms. However, diverse psychological support or psychotherapy was performed with psilocybin treatment. This study aimed to explore the association of psychological protocols with the efficacy of psilocybin-assisted therapy for depressive symptoms.<h4>Method</h4>Five major databases were systemic searched for clinical trials addressing psilocybin-assisted therapy for patients with clinical depressive symptoms. A Bayesian random-effects meta-analysis and meta-regression were performed. The effect size was mean difference (with 95% credible interval) measured by 17-Item Hamilton Depression Rating Scale.<h4>Results</h4>There were 10 eligible studies including 515 adult patients with clinicallyFrontiers in psychiatry1439347https://www.ebi.ac.uk/biostudies/studies/S-EPMC11347349biostudies-literatureThe association between diverse psychological protocols and the efficacy of psilocybin-assisted therapy for clinical depressive symptoms: a Bayesian meta-analysis.PMC11347349Yang FCTseng PTKao YCChen MHYu CLLiang CSCheng SLHsu CWHsu TWThompson TfalseThe association between diverse psychological protocols and the efficacy of psilocybin-assisted therapy for clinical depressive symptoms: a Bayesian meta-analysis.<h4>Objective</h4>Psilocybin-assisted therapy has shown promising efficacy on clinical depressive symptoms. However, diverse psychological support or psychotherapy was performed with psilocybin treatment. This study aimed to explore the association of psychological protocols with the efficacy of psilocybin-assisted therapy for depressive symptoms.<h4>Method</h4>Five major databases were systemic searched for clinical trials addressing psilocybin-assisted therapy for patients with clinical depressive symptoms. A Bayesian random-effects meta-analysis and meta-regression were performed. The effect size was mean difference (with 95% credible interval) measured by 17-Item Hamilton Depression Rating Scale.<h4>Results</h4>There were 10 eligible studies including 515 adult patients with clinically2024-01-01T00:00:00Z20242025-04-19T14:51:05.313Z2025-04-19T14:51:05.313ZS-EPMC113473493919358310.3389/fpsyt.2024.1439347