{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Z"],"funding":["Natural Science Foundation of Shaanxi Province","National Natural Science Foundation of China"],"pagination":["e2406228"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11347995"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(32)"],"pubmed_abstract":["The transition metal-catalyzed multi-component cross-electrophile sulfonylation, which incorporates SO<sub>2</sub> as a linker within organic frameworks, has proven to be a powerful, efficient, and cost-effective means of synthesizing challenging alkyl-alkyl sulfones. Transition metal catalysts play a crucial role in this method by transferring electrons from reductants to electrophilic organohalides, thereby causing undesirable side reactions such as homocoupling, protodehalogenation, β-hydride elimination, etc. It is worth noting that tertiary alkyl halides have rarely been demonstrated to be compatible with current methods owing to various undesired side reactions. In this work, a zinc-promoted cross-electrophile sulfonylation is developed through a radical-polar crossover pathway. This approach enables the synthesis of various alkyl-alkyl sulfones, including 1°-1°, 2°-1°, 3°-1°, 2°-2°, and 3°-2° types, from inexpensive and readily available alkyl halides. Various functional groups are well tolerated in the work, resulting in yields of up to 93%. Additionally, this protocol has been successfully applied to intramolecular sulfonylation and homo-sulfonylation reactions. The insights gained from this work shall be useful for the further development of cross-electrophile sulfonylation to access alkyl-alkyl sulfones."],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Zinc Promoted Cross-Electrophile Sulfonylation to Access Alkyl-Alkyl Sulfones."],"pmcid":["PMC11347995"],"funding_grant_id":["22003006","2023-JC-QN-0102","2023‐JC‐QN‐0102"],"pubmed_authors":["Ma R","Gu C","Bai R","Shi R","He X","Wang Z","Shi H"],"additional_accession":[]},"is_claimable":false,"name":"Zinc Promoted Cross-Electrophile Sulfonylation to Access Alkyl-Alkyl Sulfones.","description":"The transition metal-catalyzed multi-component cross-electrophile sulfonylation, which incorporates SO<sub>2</sub> as a linker within organic frameworks, has proven to be a powerful, efficient, and cost-effective means of synthesizing challenging alkyl-alkyl sulfones. Transition metal catalysts play a crucial role in this method by transferring electrons from reductants to electrophilic organohalides, thereby causing undesirable side reactions such as homocoupling, protodehalogenation, β-hydride elimination, etc. It is worth noting that tertiary alkyl halides have rarely been demonstrated to be compatible with current methods owing to various undesired side reactions. In this work, a zinc-promoted cross-electrophile sulfonylation is developed through a radical-polar crossover pathway. This approach enables the synthesis of various alkyl-alkyl sulfones, including 1°-1°, 2°-1°, 3°-1°, 2°-2°, and 3°-2° types, from inexpensive and readily available alkyl halides. Various functional groups are well tolerated in the work, resulting in yields of up to 93%. Additionally, this protocol has been successfully applied to intramolecular sulfonylation and homo-sulfonylation reactions. The insights gained from this work shall be useful for the further development of cross-electrophile sulfonylation to access alkyl-alkyl sulfones.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-03T22:50:38.569Z","creation":"2024-10-16T14:00:03.283Z"},"accession":"S-EPMC11347995","cross_references":{"pubmed":["38962907"],"doi":["10.1002/advs.202406228"]}}