biostudies-literatureWang ZNatural Science Foundation of Shaanxi ProvinceNational Natural Science Foundation of Chinae2406228https://www.ebi.ac.uk/biostudies/studies/S-EPMC11347995biostudies-literatureUnknown11(32)The transition metal-catalyzed multi-component cross-electrophile sulfonylation, which incorporates SO₂ as a linker within organic frameworks, has proven to be a powerful, efficient, and cost-effective means of synthesizing challenging alkyl-alkyl sulfones. Transition metal catalysts play a crucial role in this method by transferring electrons from reductants to electrophilic organohalides, thereby causing undesirable side reactions such as homocoupling, protodehalogenation, β-hydride elimination, etc. It is worth noting that tertiary alkyl halides have rarely been demonstrated to be compatible with current methods owing to various undesired side reactions. In this work, a zinc-promoted cross-electrophile sulfonylation is developed through a radical-polar crossover pathway. This approach enables the synthesis of various alkyl-alkyl sulfones, including 1°-1°, 2°-1°, 3°-1°, 2°-2°, and 3°-2° types, from inexpensive and readily available alkyl halides. Various functional groups are well tolerated in the work, resulting in yields of up to 93%. Additionally, this protocol has been successfully applied to intramolecular sulfonylation and homo-sulfonylation reactions. The insights gained from this work shall be useful for the further development of cross-electrophile sulfonylation to access alkyl-alkyl sulfones.Advanced science (Weinheim, Baden-Wurttemberg, Germany)Zinc Promoted Cross-Electrophile Sulfonylation to Access Alkyl-Alkyl Sulfones.PMC11347995220030062023-JC-QN-01022023‐JC‐QN‐0102Ma RGu CBai RShi RHe XWang ZShi HfalseZinc Promoted Cross-Electrophile Sulfonylation to Access Alkyl-Alkyl Sulfones.The transition metal-catalyzed multi-component cross-electrophile sulfonylation, which incorporates SO₂ as a linker within organic frameworks, has proven to be a powerful, efficient, and cost-effective means of synthesizing challenging alkyl-alkyl sulfones. Transition metal catalysts play a crucial role in this method by transferring electrons from reductants to electrophilic organohalides, thereby causing undesirable side reactions such as homocoupling, protodehalogenation, β-hydride elimination, etc. It is worth noting that tertiary alkyl halides have rarely been demonstrated to be compatible with current methods owing to various undesired side reactions. In this work, a zinc-promoted cross-electrophile sulfonylation is developed through a radical-polar crossover pathway. This approach enables the synthesis of various alkyl-alkyl sulfones, including 1°-1°, 2°-1°, 3°-1°, 2°-2°, and 3°-2° types, from inexpensive and readily available alkyl halides. Various functional groups are well tolerated in the work, resulting in yields of up to 93%. Additionally, this protocol has been successfully applied to intramolecular sulfonylation and homo-sulfonylation reactions. The insights gained from this work shall be useful for the further development of cross-electrophile sulfonylation to access alkyl-alkyl sulfones.2024-01-01T00:00:00Z2024 Aug2025-04-03T22:50:38.569Z2024-10-16T14:00:03.283ZS-EPMC113479953896290710.1002/advs.202406228