{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Glynn RA"],"funding":["HHS | NIH | National Institute of General Medical Sciences","NIAID NIH HHS","HHS | NIH | National Institute of Allergy and Infectious Diseases","NIGMS NIH HHS","HHS | NIH | National Institute of General Medical Sciences (NIGMS)","HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)"],"pagination":["628-640"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11348802"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["213(5)"],"pubmed_abstract":["In response to DNA double-strand breaks (DSBs), the ATM kinase activates NF-κB factors to stimulate gene expression changes that promote survival and allow time for cells to repair damage. In cell lines, ATM can activate NF-κB transcription factors via two independent, convergent mechanisms. One is ATM-mediated phosphorylation of nuclear NF-κB essential modulator (Nemo) protein, which leads to monoubiquitylation and export of Nemo to the cytoplasm where it engages the IκB kinase (IKK) complex to activate NF-κB. Another is DSB-triggered migration of ATM into the cytoplasm, where it promotes monoubiquitylation of Nemo and the resulting IKK-mediated activation of NF-κB. ATM has many other functions in the DSB response beyond activation of NF-κB, and Nemo activates NF-κB downstream of diverse "],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["ATM-dependent Phosphorylation of Nemo SQ Motifs Is Dispensable for Nemo-mediated Gene Expression Changes in Response to DNA Double-Strand Breaks."],"pmcid":["PMC11348802"],"funding_grant_id":["T32 GM-07229","R01 AI172163","R01 AI 130231","R01 AI112621","R01 AI 172163","F31 AI 152354","F31 AI152354","R01 AI143661","R01 AI130231","T32 GM007229","R01 AI 112621"],"pubmed_authors":["Hayer KE","Glynn RA","Bassing CH"],"additional_accession":[]},"is_claimable":false,"name":"ATM-dependent Phosphorylation of Nemo SQ Motifs Is Dispensable for Nemo-mediated Gene Expression Changes in Response to DNA Double-Strand Breaks.","description":"In response to DNA double-strand breaks (DSBs), the ATM kinase activates NF-κB factors to stimulate gene expression changes that promote survival and allow time for cells to repair damage. In cell lines, ATM can activate NF-κB transcription factors via two independent, convergent mechanisms. One is ATM-mediated phosphorylation of nuclear NF-κB essential modulator (Nemo) protein, which leads to monoubiquitylation and export of Nemo to the cytoplasm where it engages the IκB kinase (IKK) complex to activate NF-κB. Another is DSB-triggered migration of ATM into the cytoplasm, where it promotes monoubiquitylation of Nemo and the resulting IKK-mediated activation of NF-κB. ATM has many other functions in the DSB response beyond activation of NF-κB, and Nemo activates NF-κB downstream of diverse ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-07-15T12:47:49.345Z","creation":"2026-07-04T03:16:08.774Z"},"accession":"S-EPMC11348802","cross_references":{"pubmed":["39007641"],"doi":["10.4049/jimmunol.2300139"]}}