biostudies-literatureKim HNIA NIH HHSNational Institute on Aging5089-5101https://www.ebi.ac.uk/biostudies/studies/S-EPMC11350053biostudies-literatureUnknown20(8)<h4>Introduction</h4>This study derived composite scores for two novel cognitive measures, the No Practice Effect (NPE) battery and the Miami Computerized Functional Skills Assessment and Training system for use in early-stage Alzheimer's disease (AD) clinical trials. Their psychometric properties and associations with AD risk markers were compared to those of well-established measures.<h4>Methods</h4>For 291 older adults with healthy cognition or early mild cognitive impairment, Exploratory factor analyses were used to identify the factor structure of the NPE. Factor and total scores were examined for their psychometric properties and associations with AD risk biomarkers.<h4>Results</h4>Composite scores from the novel cognitive and functional measures demonstrated better psychometric propAlzheimer's & dementia : the journal of the Alzheimer's AssociationNovel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures.PMC113500535K23AG080117P30 AG066462R01AG051346K23 AG080117R01 AG051346Lee SLevine ASimoes SSchneider LSKim HRivera AMBrickman AMAndrews HGordon MLKerner NADevanand DPGoldberg TEBell SAHuber BCarlson SHarvey PDCohen DfalseNovel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures.<h4>Introduction</h4>This study derived composite scores for two novel cognitive measures, the No Practice Effect (NPE) battery and the Miami Computerized Functional Skills Assessment and Training system for use in early-stage Alzheimer's disease (AD) clinical trials. Their psychometric properties and associations with AD risk markers were compared to those of well-established measures.<h4>Methods</h4>For 291 older adults with healthy cognition or early mild cognitive impairment, Exploratory factor analyses were used to identify the factor structure of the NPE. Factor and total scores were examined for their psychometric properties and associations with AD risk biomarkers.<h4>Results</h4>Composite scores from the novel cognitive and functional measures demonstrated better psychometric prop2024-01-01T00:00:00Z2024 Aug2026-06-03T00:10:37.47Z2025-04-19T20:41:34.023ZS-EPMC113500533896312710.1002/alz.13757