{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Carson MS"],"funding":["NIH HHS"],"pagination":["2803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11352691"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(16)"],"pubmed_abstract":["Obesity is an established risk and progression factor for triple-negative breast cancer (TNBC), but preclinical studies to delineate the mechanisms underlying the obesity-TNBC link as well as strategies to break that link are constrained by the lack of tumor models syngeneic to obesity-prone mouse strains. C3(1)/SV40 T-antigen (C3-TAg) transgenic mice on an FVB genetic background develop tumors with molecular and pathologic features that closely resemble human TNBC, but FVB mice are resistant to diet-induced obesity (DIO). Herein, we sought to develop transplantable C3-TAg cell lines syngeneic to C57BL/6 mice, an inbred mouse strain that is sensitive to DIO. We backcrossed FVB-Tg(C3-1-TAg)cJeg/JegJ to C57BL/6 mice for ten generations, and spontaneous tumors from those mice were excised and"],"journal":["Cancers"],"pubmed_title":["Development and Characterization of Syngeneic Orthotopic Transplant Models of Obesity-Responsive Triple-Negative Breast Cancer in C57BL/6J Mice."],"pmcid":["PMC11352691"],"funding_grant_id":["CA16086","R01-CA148761","R01-CA232589","P50-CA058223"],"pubmed_authors":["VerHague M","Rezeli ET","Carson MS","Hursting SD","Coleman MF","Albright J","French JE","Roth D","Perou CM","Radler PD"],"additional_accession":[]},"is_claimable":false,"name":"Development and Characterization of Syngeneic Orthotopic Transplant Models of Obesity-Responsive Triple-Negative Breast Cancer in C57BL/6J Mice.","description":"Obesity is an established risk and progression factor for triple-negative breast cancer (TNBC), but preclinical studies to delineate the mechanisms underlying the obesity-TNBC link as well as strategies to break that link are constrained by the lack of tumor models syngeneic to obesity-prone mouse strains. C3(1)/SV40 T-antigen (C3-TAg) transgenic mice on an FVB genetic background develop tumors with molecular and pathologic features that closely resemble human TNBC, but FVB mice are resistant to diet-induced obesity (DIO). Herein, we sought to develop transplantable C3-TAg cell lines syngeneic to C57BL/6 mice, an inbred mouse strain that is sensitive to DIO. We backcrossed FVB-Tg(C3-1-TAg)cJeg/JegJ to C57BL/6 mice for ten generations, and spontaneous tumors from those mice were excised and","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-26T11:40:46.756Z","creation":"2025-04-06T13:44:06.874Z"},"accession":"S-EPMC11352691","cross_references":{"pubmed":["39199576"],"doi":["10.3390/cancers16162803"]}}