{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(35)"],"submitter":["Zhou Q"],"pubmed_abstract":["ESKAPE pathogens are a panel of most recalcitrant bacteria that could \"escape\" the treatment of antibiotics and exhibit high incidence of drug resistance. The emergence of multidrug-resistant (MDR) ESKAPE pathogens (particularly Gram-negative bacteria) accounts for high risk of mortality and increased resource utilization in health care. Worse still, there has been no new class of antibiotics approved for exterminating the Gram-negative bacteria for more than 50 years. Therefore, it is urgent to develop novel antibacterial agents with low resistance and potent killing efficacy against Gram-negative ESKAPE pathogens. Herein, we present a class of fluoropolymers by mimicking the amphiphilicity of cationic antimicrobial peptides. Our optimal fluoroamphiphilic polymer (PD<sub>45</sub>HF<sub>5<"],"journal":["Science advances"],"pagination":["eadp6604"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11352906"],"repository":["biostudies-literature"],"pubmed_title":["Fluoroamphiphilic polymers exterminate multidrug-resistant Gram-negative ESKAPE pathogens while attenuating drug resistance."],"pmcid":["PMC11352906"],"pubmed_authors":["Yu L","Zhou Q","Chen J","Si Z","Li P","Hong W","Li K","Chai J","Wang K"],"additional_accession":[]},"is_claimable":false,"name":"Fluoroamphiphilic polymers exterminate multidrug-resistant Gram-negative ESKAPE pathogens while attenuating drug resistance.","description":"ESKAPE pathogens are a panel of most recalcitrant bacteria that could \"escape\" the treatment of antibiotics and exhibit high incidence of drug resistance. The emergence of multidrug-resistant (MDR) ESKAPE pathogens (particularly Gram-negative bacteria) accounts for high risk of mortality and increased resource utilization in health care. Worse still, there has been no new class of antibiotics approved for exterminating the Gram-negative bacteria for more than 50 years. Therefore, it is urgent to develop novel antibacterial agents with low resistance and potent killing efficacy against Gram-negative ESKAPE pathogens. Herein, we present a class of fluoropolymers by mimicking the amphiphilicity of cationic antimicrobial peptides. Our optimal fluoroamphiphilic polymer (PD<sub>45</sub>HF<sub>5<","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-26T11:34:32.118Z","creation":"2025-04-06T13:46:15.535Z"},"accession":"S-EPMC11352906","cross_references":{"pubmed":["39196947"],"doi":["10.1126/sciadv.adp6604"]}}