{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(16)"],"submitter":["Borges VFA"],"pubmed_abstract":["Cholangiopathy has been described in survivors of severe COVID-19, presenting significant clinical parallels to the pre-pandemic condition of secondary sclerosing cholangitis in critically ill patients (SSC-CIP). We aimed to examine the liver histopathology of individuals with persistent cholestasis after severe COVID-19.<h4>Methods</h4>We subjected post-COVID-19 cholestasis liver samples to routine staining techniques and cytokeratin 7 immunostaining and semi-quantitatively analyzed the portal and parenchymal changes.<h4>Results</h4>All ten patients, five men, had a median age of 56, an interquartile range (IQR) of 51-60, and required intensive care unit and mechanical ventilation. The median and IQR liver enzyme concentrations proximal to biopsy were in IU/L: ALP 645 (390-1256); GGT 925 "],"journal":["Diagnostics (Basel, Switzerland)"],"pagination":["1804"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11354040"],"repository":["biostudies-literature"],"pubmed_title":["COVID-19-Related Cholangiopathy: Histological Findings."],"pmcid":["PMC11354040"],"pubmed_authors":["Borges VFA","Silva MC","Freitas LAR","Andrade ARCF","Salomao FC","Cotrim HP","Mendes LSC","Penna FGC"],"additional_accession":[]},"is_claimable":false,"name":"COVID-19-Related Cholangiopathy: Histological Findings.","description":"Cholangiopathy has been described in survivors of severe COVID-19, presenting significant clinical parallels to the pre-pandemic condition of secondary sclerosing cholangitis in critically ill patients (SSC-CIP). We aimed to examine the liver histopathology of individuals with persistent cholestasis after severe COVID-19.<h4>Methods</h4>We subjected post-COVID-19 cholestasis liver samples to routine staining techniques and cytokeratin 7 immunostaining and semi-quantitatively analyzed the portal and parenchymal changes.<h4>Results</h4>All ten patients, five men, had a median age of 56, an interquartile range (IQR) of 51-60, and required intensive care unit and mechanical ventilation. The median and IQR liver enzyme concentrations proximal to biopsy were in IU/L: ALP 645 (390-1256); GGT 925 ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-04T10:38:18.775Z","creation":"2024-10-16T14:22:11.314Z"},"accession":"S-EPMC11354040","cross_references":{"pubmed":["39202292"],"doi":["10.3390/diagnostics14161804"]}}