biostudies-literatureUnknown14(16)Borges VFACholangiopathy has been described in survivors of severe COVID-19, presenting significant clinical parallels to the pre-pandemic condition of secondary sclerosing cholangitis in critically ill patients (SSC-CIP). We aimed to examine the liver histopathology of individuals with persistent cholestasis after severe COVID-19.<h4>Methods</h4>We subjected post-COVID-19 cholestasis liver samples to routine staining techniques and cytokeratin 7 immunostaining and semi-quantitatively analyzed the portal and parenchymal changes.<h4>Results</h4>All ten patients, five men, had a median age of 56, an interquartile range (IQR) of 51-60, and required intensive care unit and mechanical ventilation. The median and IQR liver enzyme concentrations proximal to biopsy were in IU/L: ALP 645 (390-1256); GGT 925 Diagnostics (Basel, Switzerland)1804https://www.ebi.ac.uk/biostudies/studies/S-EPMC11354040biostudies-literatureCOVID-19-Related Cholangiopathy: Histological Findings.PMC11354040Borges VFASilva MCFreitas LARAndrade ARCFSalomao FCCotrim HPMendes LSCPenna FGCfalseCOVID-19-Related Cholangiopathy: Histological Findings.Cholangiopathy has been described in survivors of severe COVID-19, presenting significant clinical parallels to the pre-pandemic condition of secondary sclerosing cholangitis in critically ill patients (SSC-CIP). We aimed to examine the liver histopathology of individuals with persistent cholestasis after severe COVID-19.<h4>Methods</h4>We subjected post-COVID-19 cholestasis liver samples to routine staining techniques and cytokeratin 7 immunostaining and semi-quantitatively analyzed the portal and parenchymal changes.<h4>Results</h4>All ten patients, five men, had a median age of 56, an interquartile range (IQR) of 51-60, and required intensive care unit and mechanical ventilation. The median and IQR liver enzyme concentrations proximal to biopsy were in IU/L: ALP 645 (390-1256); GGT 925 2024-01-01T00:00:00Z2024 Aug2025-04-04T10:38:18.775Z2024-10-16T14:22:11.314ZS-EPMC113540403920229210.3390/diagnostics14161804