{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang X"],"funding":["the Shenzhen Science and Technology Programme","Shenzhen Agricultural Development Special Funds (Fishery) Agricultural High-Tech Project","the National Key Research and Development Programme of China","the Natural Science Foundation of Guangdong Province","the National Key Research and Development Programme"],"pagination":["371"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11355499"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(8)"],"pubmed_abstract":["<i>Aurantiochytrium</i> is a well-known long-chain polyunsaturated fatty acids (PUFAs) producer, especially docosahexaenoic acid (DHA). In order to reduce the cost or improve the productivity of DHA, many researchers are focusing on exploring the high-yield strain, reducing production costs, changing culture conditions, and other measures. In this study, DHA production was improved by a two-stage fermentation. In the first stage, efficient and cheap soybean powder was used instead of conventional peptone, and the optimization of fermentation conditions (optimal fermentation conditions: temperature 28.7 °C, salinity 10.7‱, nitrogen source concentration 1.01 g/L, and two-nitrogen ratio of yeast extract to soybean powder 2:1) based on response surface methodology resulted in a 1.68-fold incre"],"journal":["Marine drugs"],"pubmed_title":["Comparative Transcriptomic Analysis on the Effect of Sesamol on the Two-Stages Fermentation of <i>Aurantiochytrium</i> sp. for Enhancing DHA Accumulation."],"pmcid":["PMC11355499"],"funding_grant_id":["2021-928","2020YFD0901002","2021A1515012557","2018YFA0902500","KCXST20221021111206015 and KCXFZ20201221173404012"],"pubmed_authors":["Yang X","Liang S","Li S","Wang Z","Wei L"],"additional_accession":[]},"is_claimable":false,"name":"Comparative Transcriptomic Analysis on the Effect of Sesamol on the Two-Stages Fermentation of <i>Aurantiochytrium</i> sp. for Enhancing DHA Accumulation.","description":"<i>Aurantiochytrium</i> is a well-known long-chain polyunsaturated fatty acids (PUFAs) producer, especially docosahexaenoic acid (DHA). In order to reduce the cost or improve the productivity of DHA, many researchers are focusing on exploring the high-yield strain, reducing production costs, changing culture conditions, and other measures. In this study, DHA production was improved by a two-stage fermentation. In the first stage, efficient and cheap soybean powder was used instead of conventional peptone, and the optimization of fermentation conditions (optimal fermentation conditions: temperature 28.7 °C, salinity 10.7‱, nitrogen source concentration 1.01 g/L, and two-nitrogen ratio of yeast extract to soybean powder 2:1) based on response surface methodology resulted in a 1.68-fold incre","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-19T20:39:56.508Z","creation":"2025-04-19T20:39:56.508Z"},"accession":"S-EPMC11355499","cross_references":{"pubmed":["39195487"],"doi":["10.3390/md22080371"]}}