{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(8)"],"submitter":["Blanco CM"],"pubmed_abstract":["Elucidation of pathways regulating parasite cell death is believed to contribute to identification of novel therapeutic targets for protozoan diseases, and in this context, apoptosis-like cell death has been reported in different groups of protozoa, in which metacaspases seem to play a role. In the genus <i>Plasmodium</i>, apoptotic markers have been detected in <i>P. falciparum</i> and <i>P. berghei</i>, and no study focusing on <i>P. vivax</i> cell death has been reported so far. In the present study, we investigated the susceptibility of <i>P. vivax</i> to undergo apoptotic cell death after incubating mature trophozoites with the classical apoptosis inducer staurosporine. As assessed by flow cytometry assays, staurosporine inhibited parasite intraerythrocytic development, which was acco"],"journal":["Pathogens (Basel, Switzerland)"],"pagination":["673"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11357032"],"repository":["biostudies-literature"],"pubmed_title":["Cell Death of <i>P. vivax</i> Blood Stages Occurs in Absence of Classical Apoptotic Events and Induces Eryptosis of Parasitized Host Cells."],"pmcid":["PMC11357032"],"pubmed_authors":["Martins PDC","Lopes SCP","Chaves YO","Almeida-Silva J","Daniel-Ribeiro CT","de Souza HADS","Pratt-Riccio LR","Suarez-Fontes AM","Vannier-Santos MA","Blanco CM","Totino PRR"],"additional_accession":[]},"is_claimable":false,"name":"Cell Death of <i>P. vivax</i> Blood Stages Occurs in Absence of Classical Apoptotic Events and Induces Eryptosis of Parasitized Host Cells.","description":"Elucidation of pathways regulating parasite cell death is believed to contribute to identification of novel therapeutic targets for protozoan diseases, and in this context, apoptosis-like cell death has been reported in different groups of protozoa, in which metacaspases seem to play a role. In the genus <i>Plasmodium</i>, apoptotic markers have been detected in <i>P. falciparum</i> and <i>P. berghei</i>, and no study focusing on <i>P. vivax</i> cell death has been reported so far. In the present study, we investigated the susceptibility of <i>P. vivax</i> to undergo apoptotic cell death after incubating mature trophozoites with the classical apoptosis inducer staurosporine. As assessed by flow cytometry assays, staurosporine inhibited parasite intraerythrocytic development, which was acco","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-05-31T22:54:29.684Z","creation":"2024-11-11T18:50:18.515Z"},"accession":"S-EPMC11357032","cross_references":{"pubmed":["39204273"],"doi":["10.3390/pathogens13080673"]}}