biostudies-literatureUnknown13(8)Blanco CMElucidation of pathways regulating parasite cell death is believed to contribute to identification of novel therapeutic targets for protozoan diseases, and in this context, apoptosis-like cell death has been reported in different groups of protozoa, in which metacaspases seem to play a role. In the genus <i>Plasmodium</i>, apoptotic markers have been detected in <i>P. falciparum</i> and <i>P. berghei</i>, and no study focusing on <i>P. vivax</i> cell death has been reported so far. In the present study, we investigated the susceptibility of <i>P. vivax</i> to undergo apoptotic cell death after incubating mature trophozoites with the classical apoptosis inducer staurosporine. As assessed by flow cytometry assays, staurosporine inhibited parasite intraerythrocytic development, which was accoPathogens (Basel, Switzerland)673https://www.ebi.ac.uk/biostudies/studies/S-EPMC11357032biostudies-literatureCell Death of <i>P. vivax</i> Blood Stages Occurs in Absence of Classical Apoptotic Events and Induces Eryptosis of Parasitized Host Cells.PMC11357032Martins PDCLopes SCPChaves YOAlmeida-Silva JDaniel-Ribeiro CTde Souza HADSPratt-Riccio LRSuarez-Fontes AMVannier-Santos MABlanco CMTotino PRRfalseCell Death of <i>P. vivax</i> Blood Stages Occurs in Absence of Classical Apoptotic Events and Induces Eryptosis of Parasitized Host Cells.Elucidation of pathways regulating parasite cell death is believed to contribute to identification of novel therapeutic targets for protozoan diseases, and in this context, apoptosis-like cell death has been reported in different groups of protozoa, in which metacaspases seem to play a role. In the genus <i>Plasmodium</i>, apoptotic markers have been detected in <i>P. falciparum</i> and <i>P. berghei</i>, and no study focusing on <i>P. vivax</i> cell death has been reported so far. In the present study, we investigated the susceptibility of <i>P. vivax</i> to undergo apoptotic cell death after incubating mature trophozoites with the classical apoptosis inducer staurosporine. As assessed by flow cytometry assays, staurosporine inhibited parasite intraerythrocytic development, which was acco2024-01-01T00:00:00Z2024 Aug2025-05-31T22:54:29.684Z2024-11-11T18:50:18.515ZS-EPMC113570323920427310.3390/pathogens13080673