{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garcia-Sobrino R"],"funding":["Instituto de Salud Carlos III","Ministerio de Ciencia, Innovación y Universidades","Agencia Estatal de Investigación"],"pagination":["1063"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11359487"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(8)"],"pubmed_abstract":["New clinical strategies for treating severe bone and cartilage injuries are required, especially for use in combination with implant procedures. For this purpose, p(VCL-co-HEMA) thermosensitive hydrogels have been activated with icariin-loaded nanoparticles to be used as bone-cell-harvesting platforms. Supercritical CO<sub>2</sub>-SAS technology has been applied to encapsulate icariin, a small molecule that is involved in osteoblastic differentiation. Thus, physical-chemical analysis, including swelling and transmittance, showed the impact of HEMA groups in hydrogel composition. Moreover, icariin (ICA) release from p(VCL-co-HEMA) platforms, including pVCL@ICA nanoparticles, has been studied to evaluate their efficacy in relevant conditions. Finally, the thermosensitive hydrogels' cell comp"],"journal":["Pharmaceutics"],"pubmed_title":["Osteoblastic Cell Sheet Engineering Using P(VCL-HEMA)-Based Thermosensitive Hydrogels Doped with pVCL@Icariin Nanoparticles Obtained with Supercritical CO<sub>2</sub>-SAS."],"pmcid":["PMC11359487"],"funding_grant_id":["RTI2018-096328-B-I00","PI21/00858","PDC2022-133446-I00"],"pubmed_authors":["Reinecke H","Elvira C","Garcia-Crespo A","Martinez-Campos E","Rodriguez-Hernandez J","Casado-Losada I","Garcia C","Garcia-Sobrino R","Caltagirone C","Gallardo A"],"additional_accession":[]},"is_claimable":false,"name":"Osteoblastic Cell Sheet Engineering Using P(VCL-HEMA)-Based Thermosensitive Hydrogels Doped with pVCL@Icariin Nanoparticles Obtained with Supercritical CO<sub>2</sub>-SAS.","description":"New clinical strategies for treating severe bone and cartilage injuries are required, especially for use in combination with implant procedures. For this purpose, p(VCL-co-HEMA) thermosensitive hydrogels have been activated with icariin-loaded nanoparticles to be used as bone-cell-harvesting platforms. Supercritical CO<sub>2</sub>-SAS technology has been applied to encapsulate icariin, a small molecule that is involved in osteoblastic differentiation. Thus, physical-chemical analysis, including swelling and transmittance, showed the impact of HEMA groups in hydrogel composition. Moreover, icariin (ICA) release from p(VCL-co-HEMA) platforms, including pVCL@ICA nanoparticles, has been studied to evaluate their efficacy in relevant conditions. Finally, the thermosensitive hydrogels' cell comp","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-04T10:38:56.37Z","creation":"2024-10-16T14:29:23.649Z"},"accession":"S-EPMC11359487","cross_references":{"pubmed":["39204408"],"doi":["10.3390/pharmaceutics16081063"]}}