{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(34)"],"submitter":["Debnath S"],"pubmed_abstract":["The goal of this study was to use coevaporation to look into how polyether compounds like mephenesin (MEP) can be encapsulated into the host molecule α-cyclodextrin's nanohydrophobic cage. Fourier transform infrared spectroscopy (FT-IR) investigations, powder X-ray diffraction (PXRD), and <sup>1</sup>H NMR were among the spectroscopic techniques used to describe the inclusion complex. Additionally, Job's plot has been utilized to illustrate how MEP is encapsulated with α-cyclodextrin (α-CD) at a 1:1 molar ratio. The thermal stability of MEP increased after encapsulation according to thermogravimetric analysis (TGA) and differential thermal analysis (DTA) experiments. Mephenesin fits into the cavity of α-cyclodextrin in a 1:1 ratio, as observed by molecular docking for the inclusion complex"],"journal":["ACS omega"],"pagination":["36066-36075"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11359629"],"repository":["biostudies-literature"],"pubmed_title":["Investigation of Host-Guest Inclusion Complex of Mephenesin with α-Cyclodextrin for Innovative Application in Biological System."],"pmcid":["PMC11359629"],"pubmed_authors":["Maji J","Ghosh B","Debnath S","Mondal M","Mallick K","Sinha A","Roy MN","Dey S","Roy N","Sahana S","Kumar A"],"additional_accession":[]},"is_claimable":false,"name":"Investigation of Host-Guest Inclusion Complex of Mephenesin with α-Cyclodextrin for Innovative Application in Biological System.","description":"The goal of this study was to use coevaporation to look into how polyether compounds like mephenesin (MEP) can be encapsulated into the host molecule α-cyclodextrin's nanohydrophobic cage. Fourier transform infrared spectroscopy (FT-IR) investigations, powder X-ray diffraction (PXRD), and <sup>1</sup>H NMR were among the spectroscopic techniques used to describe the inclusion complex. Additionally, Job's plot has been utilized to illustrate how MEP is encapsulated with α-cyclodextrin (α-CD) at a 1:1 molar ratio. The thermal stability of MEP increased after encapsulation according to thermogravimetric analysis (TGA) and differential thermal analysis (DTA) experiments. Mephenesin fits into the cavity of α-cyclodextrin in a 1:1 ratio, as observed by molecular docking for the inclusion complex","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-26T11:36:15.937Z","creation":"2025-04-06T13:46:40.001Z"},"accession":"S-EPMC11359629","cross_references":{"pubmed":["39220532"],"doi":["10.1021/acsomega.3c08185"]}}