biostudies-literatureAnesi GLNHLBI NIH HHS100005https://www.ebi.ac.uk/biostudies/studies/S-EPMC11360720biostudies-literatureUnknown1(1)<h4>Background</h4>Hospital adaptation and resiliency, required during public health emergencies to optimize outcomes, are understudied especially in resource-limited settings.<h4>Research question</h4>What are the prepandemic and pandemic critical illness outcomes in a resource-limited setting and in the context of capacity strain?<h4>Study design and methods</h4>We performed a retrospective cohort study among patients admitted to ICUs at two public hospitals in the KwaZulu-Natal Department of Health in South Africa preceding and during the COVID-19 pandemic (2017-2022). We used multivariate logistic regression to analyze the association between three patient cohorts (prepandemic non-COVID-19, pandemic non-COVID-19, and pandemic COVID-19) and ICU capacity strain and the primary outcome ofCHEST critical careICU Mortality Across Prepandemic and Pandemic Cohorts in a Resource-Limited Setting: A Critical Care Resiliency Analysis From South Africa.PMC11360720K23 HL161353Hyman RWise RDSavarimuthu SMSmith MTDRamkillawan AInvernizzi JAnesi GLEddey CfalseICU Mortality Across Prepandemic and Pandemic Cohorts in a Resource-Limited Setting: A Critical Care Resiliency Analysis From South Africa.<h4>Background</h4>Hospital adaptation and resiliency, required during public health emergencies to optimize outcomes, are understudied especially in resource-limited settings.<h4>Research question</h4>What are the prepandemic and pandemic critical illness outcomes in a resource-limited setting and in the context of capacity strain?<h4>Study design and methods</h4>We performed a retrospective cohort study among patients admitted to ICUs at two public hospitals in the KwaZulu-Natal Department of Health in South Africa preceding and during the COVID-19 pandemic (2017-2022). We used multivariate logistic regression to analyze the association between three patient cohorts (prepandemic non-COVID-19, pandemic non-COVID-19, and pandemic COVID-19) and ICU capacity strain and the primary outcome of2023-01-01T00:00:00Z2023 Jun2025-04-26T14:27:46.136Z2024-11-09T17:34:54.056ZS-EPMC113607203921157610.1016/j.chstcc.2023.100005