{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garg R"],"funding":["National Institute of Neurological Disorders and Stroke","National Center for Research Resources","NCRR NIH HHS","National Institutes of Health","National Institute of General Medical Sciences","NIGMS NIH HHS","National Science Foundation"],"pagination":["107726"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11364148"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["365"],"pubmed_abstract":["Improving the spectral sensitivity and resolution of biological solids is one of the long-standing problems in nuclear magnetic resonance (NMR) spectroscopy. In this report, we introduce low-power supercycled variants of two-pulse phase-modulated (TPPM) sequence for heteronuclear decoupling. The utility of the sequence is shown by improvements in the transverse relaxation time of observed nuclei (with <sup>1</sup>H decoupling) with its application to different samples (uniformly <sup>13</sup>C, <sup>15</sup>N, <sup>2</sup>H-labeled GB1 back-exchanged with 25% H<sub>2</sub>O and 75% D<sub>2</sub>O, uniformly <sup>13</sup>C, <sup>15</sup>N, <sup>2</sup>H-labeled human derived Asyn fibril back-exchanged with 100% H<sub>2</sub>O and uniformly <sup>13</sup>C, <sup>15</sup>N -labeled human deriv"],"journal":["Journal of magnetic resonance (San Diego, Calif. : 1997)"],"pubmed_title":["Low power supercycled TPPM decoupling."],"pmcid":["PMC11364148"],"funding_grant_id":["DBI 1946970","P41GM136463","S10RR025037","P41 GM136463","S10 RR025037"],"pubmed_authors":["Garg R","Rienstra CM","DeZonia B","Paterson AL"],"additional_accession":[]},"is_claimable":false,"name":"Low power supercycled TPPM decoupling.","description":"Improving the spectral sensitivity and resolution of biological solids is one of the long-standing problems in nuclear magnetic resonance (NMR) spectroscopy. In this report, we introduce low-power supercycled variants of two-pulse phase-modulated (TPPM) sequence for heteronuclear decoupling. The utility of the sequence is shown by improvements in the transverse relaxation time of observed nuclei (with <sup>1</sup>H decoupling) with its application to different samples (uniformly <sup>13</sup>C, <sup>15</sup>N, <sup>2</sup>H-labeled GB1 back-exchanged with 25% H<sub>2</sub>O and 75% D<sub>2</sub>O, uniformly <sup>13</sup>C, <sup>15</sup>N, <sup>2</sup>H-labeled human derived Asyn fibril back-exchanged with 100% H<sub>2</sub>O and uniformly <sup>13</sup>C, <sup>15</sup>N -labeled human deriv","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-03-18T13:25:36.69Z","creation":"2025-08-18T09:53:54.471Z"},"accession":"S-EPMC11364148","cross_references":{"pubmed":["38991267"],"doi":["10.1016/j.jmr.2024.107726"]}}