{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li TA"],"funding":["Flight Attendant Medical Research Institute","NIA NIH HHS","NIAID NIH HHS","National Disease Research Interchange","FDA HHS","NHLBI NIH HHS","National Institutes of Health","NIH HHS","Food and Drug Administration","NIGMS NIH HHS"],"pagination":["cwae065"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11364441"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(10)"],"pubmed_abstract":["Human sialic acid-binding immunoglobulin-like lectins (Siglecs) are expressed on subsets of immune cells. Siglec-8 is an immune inhibitory Siglec on eosinophils and mast cells, which are effectors in allergic disorders including eosinophilic esophagitis. Inhibition occurs when Siglec-8 is crosslinked by multivalent Siglec ligands in target tissues. Previously we discovered a high-affinity Siglec-8 sialoglycan ligand on human airways composed of terminally sialylated keratan sulfate chains carried on a single protein, DMBT1. Here we extend that approach to another allergic inflammatory target tissue, human esophagus. Lectin overlay histochemistry revealed that Siglec-8 ligands are expressed predominantly by esophageal submucosal glands, and are densely packed in submucosal ducts leading to "],"journal":["Glycobiology"],"pubmed_title":["Sialylated keratan sulfates on MUC5B are Siglec-8 ligands in the human esophagus."],"pmcid":["PMC11364441"],"funding_grant_id":["R01 FD004086","R01 AG064908","T32 GM135083","HL141952","GM135083","K12 HL141952","FD004086","U19 AI136443","AG064908","U42 OD011158","AI136443","U42OD11158"],"pubmed_authors":["Schnaar RL","Awol AK","Gonzalez-Gil A","Ackerman SJ","Li TA","Orsburn BC"],"additional_accession":[]},"is_claimable":false,"name":"Sialylated keratan sulfates on MUC5B are Siglec-8 ligands in the human esophagus.","description":"Human sialic acid-binding immunoglobulin-like lectins (Siglecs) are expressed on subsets of immune cells. Siglec-8 is an immune inhibitory Siglec on eosinophils and mast cells, which are effectors in allergic disorders including eosinophilic esophagitis. Inhibition occurs when Siglec-8 is crosslinked by multivalent Siglec ligands in target tissues. Previously we discovered a high-affinity Siglec-8 sialoglycan ligand on human airways composed of terminally sialylated keratan sulfate chains carried on a single protein, DMBT1. Here we extend that approach to another allergic inflammatory target tissue, human esophagus. Lectin overlay histochemistry revealed that Siglec-8 ligands are expressed predominantly by esophageal submucosal glands, and are densely packed in submucosal ducts leading to ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-05-29T17:17:36.203Z","creation":"2026-04-08T05:26:10.631Z"},"accession":"S-EPMC11364441","cross_references":{"pubmed":["39173029"],"doi":["10.1093/glycob/cwae065"]}}