{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gazi AH"],"funding":["Cooperative Studies Program","Office of Research and Development","NIA NIH HHS","NHLBI NIH HHS","National Institutes of Health","VA","NIH","U.S. Department of Veterans Affairs","National Science Foundation"],"pagination":["4912-4924"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11364449"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(8)"],"pubmed_abstract":["<h4>Background</h4>Posttraumatic stress disorder (PTSD) causes heightened fight-or-flight responses to traumatic memories (i.e., hyperarousal). Although hyperarousal is hypothesized to cause irregular breathing (i.e., respiratory variability), no quantitative markers of respiratory variability have been shown to correspond with PTSD symptoms in humans.<h4>Objective</h4>In this study, we define interpretable markers of respiration pattern variability (RPV) and investigate whether these markers respond during traumatic memories, correlate with PTSD symptoms, and differ in patients with PTSD.<h4>Methods</h4>We recruited 156 veterans from the Vietnam-Era Twin Registry to participate in a trauma recall protocol. From respiratory effort and electrocardiogram measurements, we extracted respirator"],"journal":["IEEE journal of biomedical and health informatics"],"pubmed_title":["Quantifying Posttraumatic Stress Disorder Symptoms During Traumatic Memories Using Interpretable Markers of Respiratory Variability."],"pmcid":["PMC11364449"],"funding_grant_id":["K24 HL077506","DGE-2039655","R01 HL68630","2K24 HL077506","K23 HL127251","R01 HL125246","CSP #256","R01 HL136205","R01 HL068630","R01 AG026255"],"pubmed_authors":["Tarlapally N","Haffar A","Alday EAP","Bremner JD","Saks GL","Sanchez-Perez JA","Shah AJ","Ahmed H","Herraka D","Smith NL","Inan OT","Vaccarino V","Gazi AH"],"additional_accession":[]},"is_claimable":false,"name":"Quantifying Posttraumatic Stress Disorder Symptoms During Traumatic Memories Using Interpretable Markers of Respiratory Variability.","description":"<h4>Background</h4>Posttraumatic stress disorder (PTSD) causes heightened fight-or-flight responses to traumatic memories (i.e., hyperarousal). Although hyperarousal is hypothesized to cause irregular breathing (i.e., respiratory variability), no quantitative markers of respiratory variability have been shown to correspond with PTSD symptoms in humans.<h4>Objective</h4>In this study, we define interpretable markers of respiration pattern variability (RPV) and investigate whether these markers respond during traumatic memories, correlate with PTSD symptoms, and differ in patients with PTSD.<h4>Methods</h4>We recruited 156 veterans from the Vietnam-Era Twin Registry to participate in a trauma recall protocol. From respiratory effort and electrocardiogram measurements, we extracted respirator","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-03-27T17:13:18.176Z","creation":"2025-08-30T03:09:26.054Z"},"accession":"S-EPMC11364449","cross_references":{"pubmed":["38713564"],"doi":["10.1109/jbhi.2024.3397589","10.1109/JBHI.2024.3397589"]}}