biostudies-literatureUnknown13El-Toukhy S<h4>Background</h4>Postacute sequelae of COVID-19 (PASC) remain understudied in nonhospitalized patients. Digital wearables allow for a continuous collection of physiological parameters such as respiratory rate and oxygen saturation that have been predictive of disease trajectories in hospitalized patients.<h4>Objective</h4>This protocol outlines the design and procedures of a prospective, longitudinal, observational study of PASC that aims to identify wearables-collected physiological parameters that are associated with PASC in patients with a positive diagnosis.<h4>Methods</h4>This is a single-arm, prospective, observational study of a cohort of 550 patients, aged 18 to 65 years, male or female, who own a smartphone or a tablet that meets predetermined Bluetooth version and operating sysJMIR research protocolse57382https://www.ebi.ac.uk/biostudies/studies/S-EPMC11364950biostudies-literatureStudy of Postacute Sequelae of COVID-19 Using Digital Wearables: Protocol for a Prospective Longitudinal Observational Study.PMC11364950Moses NHegeman PEl-Toukhy SPowell-Wiley TMZuckerman GDas ARTroendle JfalseStudy of Postacute Sequelae of COVID-19 Using Digital Wearables: Protocol for a Prospective Longitudinal Observational Study.<h4>Background</h4>Postacute sequelae of COVID-19 (PASC) remain understudied in nonhospitalized patients. Digital wearables allow for a continuous collection of physiological parameters such as respiratory rate and oxygen saturation that have been predictive of disease trajectories in hospitalized patients.<h4>Objective</h4>This protocol outlines the design and procedures of a prospective, longitudinal, observational study of PASC that aims to identify wearables-collected physiological parameters that are associated with PASC in patients with a positive diagnosis.<h4>Methods</h4>This is a single-arm, prospective, observational study of a cohort of 550 patients, aged 18 to 65 years, male or female, who own a smartphone or a tablet that meets predetermined Bluetooth version and operating sys2024-01-01T00:00:00Z2024 Aug2026-04-17T13:20:14.827Z2025-04-06T13:44:40.989ZS-EPMC113649503915075010.2196/57382