{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(8)"],"submitter":["Li X"],"pubmed_abstract":["Osteoarthritis (OA) is an aging-associated disease characterized by joint stiffness pain and destroyed articular cartilage. Traditional treatments for OA are limited to alleviating various OA symptoms. There is a lack of drugs available in clinical practice that can truly repair cartilage damage. Here, we developed the chondroitin sulfate analog CS-semi5, semi-synthesized from chondroitin sulfate A. <i>In vivo</i>, CS-semi5 alleviated inflammation, provided analgesic effects, and protected cartilage in the modified Hulth OA rat model and papain-induced OA rat model. A bioinformatics analysis was performed on samples from OA patients and an exosome analysis on papain-induced OA rats, revealing miR-122-5p as the key regulator associated with CS-semi5 in OA treatment. Binding prediction revea"],"journal":["Acta pharmaceutica Sinica. B"],"pagination":["3528-3542"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11365380"],"repository":["biostudies-literature"],"pubmed_title":["Semi-synthetic chondroitin sulfate CS-semi5 upregulates miR-122-5p, conferring a therapeutic effect on osteoarthritis <i>via</i> the p38/MMP13 pathway."],"pmcid":["PMC11365380"],"pubmed_authors":["Li X","Yang J","Wu L","Zhang H","Chen X","Wang H","Zhou Y","Yang S","Zhao Z","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Semi-synthetic chondroitin sulfate CS-semi5 upregulates miR-122-5p, conferring a therapeutic effect on osteoarthritis <i>via</i> the p38/MMP13 pathway.","description":"Osteoarthritis (OA) is an aging-associated disease characterized by joint stiffness pain and destroyed articular cartilage. Traditional treatments for OA are limited to alleviating various OA symptoms. There is a lack of drugs available in clinical practice that can truly repair cartilage damage. Here, we developed the chondroitin sulfate analog CS-semi5, semi-synthesized from chondroitin sulfate A. <i>In vivo</i>, CS-semi5 alleviated inflammation, provided analgesic effects, and protected cartilage in the modified Hulth OA rat model and papain-induced OA rat model. A bioinformatics analysis was performed on samples from OA patients and an exosome analysis on papain-induced OA rats, revealing miR-122-5p as the key regulator associated with CS-semi5 in OA treatment. Binding prediction revea","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-07-15T10:58:16.082Z","creation":"2024-10-16T14:22:55.968Z"},"accession":"S-EPMC11365380","cross_references":{"pubmed":["39220883"],"doi":["10.1016/j.apsb.2024.05.016"]}}